成人颈部围度与代谢综合征及其组分风险的关联：一项系统评价和荟萃分析。
The association of neck circumference with risk of metabolic syndrome and its components in adults: A systematic review and meta-analysis.
作者信息
Namazi N, Larijani B, Surkan P J, Azadbakht L
机构信息
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Nutr Metab Cardiovasc Dis. 2018 Jul;28(7):657-674. doi: 10.1016/j.numecd.2018.03.006. Epub 2018 Mar 21.
BACKGROUND & AIMS: Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations.
METHODS AND RESULTS
PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers. We included studies that examined the association of NC with risk of MetS, or at minimum, one of its components as outcomes. Of 2628 publications identified, 19 papers met selection criteria. We found no association between NC and MetS (odd ratio (OR): 0.73; 95% CI: 0.003, 1.47). However, there was a positive association between NC and waist circumference (WC) (r = 0.85; 95%: 0.75, 0.95; I: 98.2%; p = 0.0001), BMI: (r:0.88; 95% CI: 0.74, 0.91, I:97.3%), triglycerides (TG) (OR: 1.87; 95% CI: 1.60, 2.19; I:58.4%; p = 0.03), TC (r:0.14; 95%CI: 0.05, 0.23, I:94.1%), LDL-C (r: 0.18; 95%CI: 0.07, 0.29, I:94.3%), hypertension (OR: 1.94; 95% CI:1.43, 2.64, I:87.3%), systolic (r: 0.21, 95%CI: 0.19, 0.23; I:67.1%) and diastolic blood pressures (r: 0.20, 95%CI: 0.16, 0.23; I:79.7%), low HDL-C (r:-0.21; 95% CI: -0.26, -0.15, I = 92.5%), as well as fasting blood sugar (FBS) concentrations (r: 0.20, 95%CI: 0.16, 0.24; I:88.1%).
CONCLUSION
Subjects with higher NC were at approximately two-fold higher risk for hypertriglyceridemia compared to those with lower NC. We found positive associations between NC, WC, BMI, hypertension, FBS, TC, LDL-C, SBP, DBP, and low HDL-C concentrations. However, heterogeneity was considerably high. Therefore, the findings should be taken with caution. Future studies using longitudinal designs are needed to further understand the association between NC and features of MetS.
背景与目的
先前的多项研究表明，颈围（NC）是代谢综合征（MetS）及其特征风险的可靠诊断工具。然而，并非所有研究都支持这一观点。因此，我们旨在进行一项荟萃分析，以总结成人群体中NC与MetS及其组成成分之间的关联。
方法与结果
检索了PubMed/Medline、Web of Knowledge和Scopus电子数据库，直至2017年5月31日，以查找相关的英文论文。我们纳入了研究NC与MetS风险关联的研究，或者至少将其组成成分之一作为研究结果的研究。在确定的2628篇出版物中，19篇符合选择标准。我们发现NC与MetS之间无关联（比值比（OR）：0.73；95%置信区间：0.003，1.47）。然而，NC与腰围（WC）之间存在正相关（r = 0.85；95%：0.75，0.95；I：98.2%；p = 0.0001），体重指数（BMI）：（r：0.88；95%置信区间：0.74，0.91，I：97.3%），甘油三酯（TG）（OR：1.87；95%置信区间：1.60，2.19；I：58.4%；p = 0.03），总胆固醇（TC）（r：0.14；95%置信区间：0.05，0.23，I：94.1%），低密度脂蛋白胆固醇（LDL-C）（r：0.18；95%置信区间：0.07，0.29，I：94.3%）高血压（OR：1.94；95%置信区间：1.43，2.64，I：87.3%），收缩压（r：0.21，95%置信区间：0.19，0.23；I：67.1%）和舒张压（r：0.20，95%置信区间：0.16，0.23；I：79.7%），低高密度脂蛋白胆固醇（HDL-C）（r：-0.21；95%置信区间：-0.26，-0.15，I = 92.5%），以及空腹血糖（FBS）浓度（r：0.20，95%置信区间：0.16，0.24；I：88.1%）。
结论
与颈围较低的受试者相比，颈围较高的受试者患高甘油三酯血症的风险大约高出两倍。我们发现NC、WC、BMI、高血压、FBS、TC、LDL-C、收缩压、舒张压和低HDL-C浓度之间存在正相关。然而，异质性相当高。因此，对这些发现应谨慎对待。需要采用纵向设计的未来研究来进一步了解NC与MetS特征之间的关联。
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