Alayan Nour, Eller Lucille, Bates Marsha E, Carmody Dennis P
1 Hariri School of Nursing, American University of Beirut , Beirut, Lebanon .
2 School of Nursing, Rutgers, The State University of New Jersey , Newark, New Jersey.
J Altern Complement Med. 2018 Nov;24(11):1039-1050. doi: 10.1089/acm.2018.0019. Epub 2018 May 21.
The limited success of conventional anticraving interventions encourages research into new treatment strategies. Heart rate variability biofeedback (HRVB), which is based on slowed breathing, was shown to improve symptom severity in various disorders. HRVB, and certain rates of controlled breathing (CB), may offer therapeutic potential as a complementary drug-free treatment option to help control substance craving.
This review evaluated current evidence on the effectiveness of HRVB and CB training as a complementary anticraving intervention, based on guidelines from the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. Studies that assessed a cardiorespiratory feedback or CB intervention with substance craving as an outcome were selected. Effect sizes were calculated for each study. The Scale for Assessing Scientific Quality of Investigations in Complementary and Alternative Medicine was used to evaluate the quality of each study reviewed.
A total of eight articles remained for final review, including controlled studies with or without randomization, as well as noncontrolled trials. Most studies showed positive results with a variety of methodological quality levels and effect size. Current HRVB studies rated moderately on methodological rigor and showed inconsistent magnitudes of calculated effect size (0.074-0.727) across populations. The largest effect size was found in a nonclinical college population of high food cravers utilizing the most intensive HRVB training time of 240 min.
Despite the limitations of this review, there is beginning evidence that HRVB and CB training can be of significant therapeutic potential. Larger clinical trials are needed with methodological improvements such as longer treatment duration, adequate control conditions, measures of adherence and compliance, longitudinal examination of craving changes, and more comprehensive methods of craving measurement.
传统的抗渴望干预措施成效有限,这促使人们对新的治疗策略展开研究。基于呼吸放缓的心率变异性生物反馈(HRVB)已被证明可改善多种疾病的症状严重程度。HRVB以及特定频率的控制呼吸(CB),可能具有治疗潜力,可作为一种辅助性的无药物治疗选择,帮助控制物质渴望。
本综述依据系统评价与Meta分析方案的首选报告项目指南,评估了HRVB和CB训练作为辅助性抗渴望干预措施有效性的现有证据。选取了以物质渴望为结果评估心肺反馈或CB干预的研究。计算每项研究的效应量。使用补充和替代医学研究科学质量评估量表来评估所审查的每项研究的质量。
共有八篇文章进入最终审查,包括有或无随机分组的对照研究以及非对照试验。大多数研究在不同的方法学质量水平和效应量方面都呈现出积极结果。当前的HRVB研究在方法学严谨性方面评级为中等,且不同人群中计算出的效应量大小不一致(0.074 - 0.727)。在一个对食物有强烈渴望的非临床大学生群体中,采用240分钟最密集的HRVB训练时间时,发现了最大的效应量。
尽管本综述存在局限性,但已有初步证据表明HRVB和CB训练可能具有显著的治疗潜力。需要开展更大规模的临床试验,并改进方法学,如延长治疗持续时间、设置充分的对照条件、测量依从性和顺应性、对渴望变化进行纵向检查以及采用更全面的渴望测量方法。