癌症中的B7-H3——超越免疫调节
B7-H3 in Cancer - Beyond Immune Regulation.
作者信息
Flem-Karlsen Karine, Fodstad Øystein, Tan Ming, Nunes-Xavier Caroline E
机构信息
Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Center for Cell Death and Metabolism Research, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
出版信息
Trends Cancer. 2018 Jun;4(6):401-404. doi: 10.1016/j.trecan.2018.03.010. Epub 2018 Apr 20.
B7-H3, a member of the B7 family of immunoregulatory proteins, is overexpressed in cancer and promotes tumor growth, metastasis, and drug resistance. We discuss here the involvement of B7-H3 in cancer that goes beyond its immune regulatory function, and discuss the potential of B7-H3 as a biomarker and therapeutic target.
B7-H3是免疫调节蛋白B7家族的一员，在癌症中过度表达，促进肿瘤生长、转移和耐药性。我们在此讨论B7-H3在癌症中的作用，其作用超出了免疫调节功能，并探讨B7-H3作为生物标志物和治疗靶点的潜力。
Zotero 插件