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加巴喷丁在患有特发性脊柱侧弯的青少年患者后路脊柱融合术后实现物理治疗目标中的效用。

Utility of gabapentin in meeting physical therapy goals following posterior spinal fusion in adolescent patients with idiopathic scoliosis.

作者信息

Thomas James J, Levek Claire, Quick Hannah D, Brinton John T, Garg Sumeet, Cohen Mindy N

机构信息

Department of Anesthesiology, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.

Department of Pediatrics, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.

出版信息

Paediatr Anaesth. 2018 Jun;28(6):558-563. doi: 10.1111/pan.13398.

Abstract

OF BACKGROUND DATA

Posterior spinal fusion surgery for scoliosis requires extensive postoperative analgesic care. In 2014, we initiated the use of gabapentin as an adjunct for multimodal pain management in spine fusion patients. The effect of gabapentin on postoperative recovery in scoliosis patients was evaluated using the time to meet postoperative physical therapy goals. This measure was chosen because the actions required to achieve the goals are specific and reproducible. Secondary outcomes included morphine equivalents and maximum pain scores.

AIMS

The purpose of this study was to evaluate the effects of gabapentin on time to achieve physical therapy goals following posterior spinal fusion in adolescents with scoliosis.

METHODS

A retrospective chart review was performed and patients treated perioperatively with gabapentin were compared with those who did not receive gabapentin. Outcome measures included the postoperative day that physical therapy goals were met, days to discharge, morphine equivalents, and maximum pain scores. The 4 physical therapy goals included logroll, transition from lying to sitting, ambulate 250 feet, and ascend/descend at least 3 stairs.

RESULTS

There were 50 patients in the gabapentin group and 51 patients in the control group. In the gabapentin group, there was a statistically significant decrease in the time required to meet physical therapy goals. Notably, gabapentin was independently associated with a 5.34 times higher odds of completion of the most challenging physical therapy goal (stairs) within 1 day (P = .04; 95% CI=1.24-37.44). There was not a statistically significant difference in length of hospital stay between the groups (P = .116; 95% CI=0-1).

CONCLUSION

In this retrospective analysis, the use of perioperative gabapentin is associated with a statistically significant decrease in time to completing physical therapy goals after spinal fusion for adolescent idiopathic scoliosis.

摘要

背景数据

脊柱侧弯后路脊柱融合手术术后需要广泛的镇痛护理。2014年,我们开始将加巴喷丁用作脊柱融合患者多模式疼痛管理的辅助药物。通过达到术后物理治疗目标的时间来评估加巴喷丁对脊柱侧弯患者术后恢复的影响。选择这一指标是因为实现这些目标所需的行动是具体且可重复的。次要结果包括吗啡当量和最大疼痛评分。

目的

本研究的目的是评估加巴喷丁对青少年脊柱侧弯患者后路脊柱融合术后达到物理治疗目标时间的影响。

方法

进行了一项回顾性病历审查,将围手术期接受加巴喷丁治疗的患者与未接受加巴喷丁治疗的患者进行比较。结果指标包括达到物理治疗目标的术后天数、出院天数、吗啡当量和最大疼痛评分。4项物理治疗目标包括翻身、从卧位转为坐位、行走250英尺以及上下至少3级楼梯。

结果

加巴喷丁组有50例患者,对照组有51例患者。在加巴喷丁组中,达到物理治疗目标所需的时间有统计学意义的显著减少。值得注意的是,加巴喷丁与在1天内完成最具挑战性的物理治疗目标(爬楼梯)的可能性高出5.34倍独立相关(P = .04;95% CI = 1.24 - 37.44)。两组之间的住院时间没有统计学意义的显著差异(P = .116;95% CI = 0 - 1)。

结论

在这项回顾性分析中,围手术期使用加巴喷丁与青少年特发性脊柱侧弯脊柱融合术后完成物理治疗目标的时间有统计学意义的显著减少相关。

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