组织工程学在颞下颌关节盘再生中的应用。
Tissue engineering toward temporomandibular joint disc regeneration.
机构信息
Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, CA 95616, USA.
Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA.
出版信息
Sci Transl Med. 2018 Jun 20;10(446). doi: 10.1126/scitranslmed.aaq1802.
Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.
治疗颞下颌关节（TMJ）盘变薄和穿孔，这些是 TMJ 病理中常见的情况，是姑息性的，而不是修复性的。为了解决这个问题，使用同种异体、传代肋软骨细胞创建了无支架组织工程植入物。压缩和生物活性刺激方案的组合产生了机械性能类似于天然盘的植入物。在小型猪中检查了修复盘变薄的疗效。与空对照相比，组织工程植入物的治疗通过诱导更完全的 4.4 倍的缺陷闭合，形成 3.4 倍更硬的修复组织，并促进 3.2 倍更硬的层内融合，从而恢复了盘的完整性。未治疗组的骨关节炎评分（表示退行性变化）是植入物治疗组的 3.0 倍。这种组织工程策略为开发组织工程植入物作为 TMJ 盘变薄的临床治疗方法铺平了道路。
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