用人冠状病毒229E对猫进行实验性接种，随后用猫传染性腹膜炎病毒进行攻毒。
Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus.
作者信息
Barlough J E, Johnson-Lussenburg C M, Stoddart C A, Jacobson R H, Scott F W
出版信息
Can J Comp Med. 1985 Jul;49(3):303-7.
Abstract
Minimal-disease cats exposed to live human coronavirus 229E developed homologous antibody responses that suggested little or no replication of the virus in inoculated animals. Oronasal and subcutaneous inoculation of coronavirus 229E did not elicit an antibody response by heterologous (transmissible gastroenteritis virus, canine coronavirus) neutralization or by heterologous (transmissible gastroenteritis virus) kinetics-based enzyme-linked immunosorbent assay. No clinical signs attributable to coronavirus 229E were seen in inoculated cats. Although the number of animals in each of the five experimental groups was small (n = 2), antibodies produced in response to the virus did not appear to sensitize cats to subsequent feline infectious peritonitis virus challenge, but neither did they cross-protect cats against the challenge dose.
摘要
暴露于活的人冠状病毒229E的微小病变猫产生了同源抗体反应，这表明该病毒在接种动物体内几乎没有复制或没有复制。经口鼻和皮下接种冠状病毒229E，通过异源（传染性胃肠炎病毒、犬冠状病毒）中和或基于异源（传染性胃肠炎病毒）动力学的酶联免疫吸附试验均未引发抗体反应。在接种的猫中未观察到可归因于冠状病毒229E的临床症状。尽管五个实验组中的每组动物数量较少（n = 2），但针对该病毒产生的抗体似乎并未使猫对随后的猫传染性腹膜炎病毒攻击敏感，也未对猫起到交叉保护作用以抵御攻击剂量。
相似文献
1
Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus.
Can J Comp Med. 1985 Jul;49(3):303-7.
2
Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus.
Lab Anim Sci. 1984 Dec;34(6):592-7.
3
An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis.
Am J Vet Res. 1981 Mar;42(3):368-77.
4
Comparison of serologic assays for measurement of antibody response to coronavirus in cats.
Am J Vet Res. 1988 Sep;49(9):1472-9.
5
Macrotiter assay for coronavirus-neutralizing activity in cats using a canine continuous cell line (A-72).
Lab Anim Sci. 1983 Dec;33(6):567-70.
6
Feline infectious peritonitis: a worldwide serosurvey.
Am J Vet Res. 1979 Oct;40(10):1487-92.
7
Epitope-specific antibody responses to virulent and avirulent feline infectious peritonitis virus isolates.
J Clin Microbiol. 1987 Aug;25(8):1529-34. doi: 10.1128/jcm.25.8.1529-1534.1987.
8
Virus shedding and immune responses in cats inoculated with cell culture-adapted feline infectious peritonitis virus.
Vet Microbiol. 1988 Feb;16(2):145-58. doi: 10.1016/0378-1135(88)90039-9.
9
Feline infectious peritonitis. An update.
Mod Vet Pract. 1978 Nov;59(11):832-6.
10
Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683.
Am J Vet Res. 1984 Dec;45(12):2580-5.
引用本文的文献
1
Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores.
J Gen Virol. 2025 Apr;106(4). doi: 10.1099/jgv.0.002092.
2
Coronavirus Infections of Animals: Future Risks to Humans.
Biol Bull Russ Acad Sci. 2021;48(1):26-37. doi: 10.1134/S1062359021010052. Epub 2021 Mar 1.
3
Serological Screening for Coronavirus Infections in Cats.
Viruses. 2019 Aug 13;11(8):743. doi: 10.3390/v11080743.
4
An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections.
BMC Vet Res. 2014 Aug 15;10:186. doi: 10.1186/s12917-014-0186-7.
5
Recombinant feline coronaviruses as vaccine candidates confer protection in SPF but not in conventional cats.
Vet Microbiol. 2014 Mar 14;169(3-4):154-62. doi: 10.1016/j.vetmic.2013.10.015. Epub 2013 Oct 29.
6
Identification and characterization of a novel alpaca respiratory coronavirus most closely related to the human coronavirus 229E.
Viruses. 2012 Dec 12;4(12):3689-700. doi: 10.3390/v4123689.
7
Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range.
J Virol. 2007 Feb;81(3):1261-73. doi: 10.1128/JVI.01510-06. Epub 2006 Nov 8.
8
FIP: a novel approach to vaccination. Proceedings from the 2nd International FCoV/FIP Symposium, Glasgow, 4-7 August 2002.
J Feline Med Surg. 2004 Apr;6(2):119-24. doi: 10.1016/j.jfms.2003.08.010.
9
Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis.
J Virol. 2004 Apr;78(8):3863-71. doi: 10.1128/jvi.78.8.3863-3871.2004.
10
Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I.
J Virol. 1996 Dec;70(12):8669-74. doi: 10.1128/JVI.70.12.8669-8674.1996.
本文引用的文献
1
Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever.
Comp Immunol Microbiol Infect Dis. 1981;4(2):175-89. doi: 10.1016/0147-9571(81)90003-5.
2
Coronaviridae.
Intervirology. 1983;20(4):181-9. doi: 10.1159/000149390.
3
Experimental studies of a coronavirus and coronavirus-like agent in a barrier-maintained feline breeding colony.
Arch Virol. 1984;79(1-2):85-94. doi: 10.1007/BF01314306.
4
Macrotiter assay for coronavirus-neutralizing activity in cats using a canine continuous cell line (A-72).
Lab Anim Sci. 1983 Dec;33(6):567-70.
5
Evaluation of a computer-assisted, kinetics-based enzyme-linked immunosorbent assay for detection of coronavirus antibodies in cats.
J Clin Microbiol. 1983 Feb;17(2):202-17. doi: 10.1128/jcm.17.2.202-217.1983.
6
Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus.
Am J Vet Res. 1983 Feb;44(2):229-34.
7
Pathogenesis of feline infetious peritonitis: pathologic changes and immunofluorescence.
Am J Vet Res. 1981 Dec;42(12):2036-48.
8
Pathogenesis of feline infectious peritonitis: nature and development of viremia.
Am J Vet Res. 1981 Mar;42(3):382-90.
9
An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis.
Am J Vet Res. 1981 Mar;42(3):368-77.
10
Immunologic phenomena in the effusive form of feline infectious peritonitis.
Am J Vet Res. 1980 Jun;41(6):868-76.
Zotero 插件