席夫碱及其金属配合物作为脲酶抑制剂——简要综述。
Schiff bases and their metal complexes as urease inhibitors - A brief review.
作者信息
de Fátima Ângelo, Pereira Camila de Paula, Olímpio Carolina Raquel Said Dau Gonçalves, de Freitas Oliveira Breno Germano, Franco Lucas Lopardi, da Silva Pedro Henrique Corrêa
机构信息
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Departamento de Alimentos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas, 37130-001 Alfenas, MG, Brazil.
出版信息
J Adv Res. 2018 Mar 26;13:113-126. doi: 10.1016/j.jare.2018.03.007. eCollection 2018 Sep.
Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms' health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. This short review compiles examples of the most antiurease Schiff bases (0.23 μM < IC < 37.00 μM) and their metal complexes (0.03 μM < IC < 100 μM). Emphasis is given to ureases of and although the active site of this class of hydrolases is conserved among living organisms.
席夫碱是一类醛或酮类化合物，其中羰基被亚胺或偶氮甲碱取代，是一些应用最为广泛的有机化合物。实际上，它们被广泛用于工业用途，还展现出广泛的生物活性，包括抗脲酶活性。脲酶是催化尿素水解的酶，因其对生物体健康的影响而受到相当多的关注，因为脲酶活性在人类和动物细胞中的持续存在可能是某些疾病和病原体感染的原因。这篇简短综述汇编了最具抗脲酶活性的席夫碱（0.23 μM < IC < 37.00 μM）及其金属配合物（0.03 μM < IC < 100 μM）的实例。尽管这类水解酶的活性位点在生物体内是保守的，但重点关注的是[此处信息缺失]和[此处信息缺失]的脲酶。
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