在人体消化液的体外胃肠道消化过程中海洋油的氧化 - 油源、添加的生育酚和脂肪酶活性的作用。
Oxidation of marine oils during in vitro gastrointestinal digestion with human digestive fluids - Role of oil origin, added tocopherols and lipolytic activity.
机构信息
Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden.
Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Science, Ås, Norway.
出版信息
Food Chem. 2019 Jan 1;270:527-537. doi: 10.1016/j.foodchem.2018.07.049. Epub 2018 Jul 10.
The formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE), 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE) in cod liver-, anchovy-, krill-, and algae oil during in vitro digestion with human gastrointestinal fluids was investigated. Adding rabbit gastric lipase, lipase inhibitor (orlistat) and tocopherols to cod liver oil, lipolysis and oxidation was also studied. Among the marine oils, the highest aldehyde levels (18 µM MDA, 3 µM HHE and 0.2 µM HNE) were detected after digestion of cod liver oil, while the lowest levels were detected in krill and algae oils. Addition of rabbit gastric lipase significantly increased the release of HNE during the digestion. Orlistat significantly reduced lipolysis and MDA formation. Formation of MDA and HHE was delayed by tocopherols, the tocopherol mix Covi-ox® T 70 EU being more effective than pure α-tocopherol.
研究了在人胃肠道消化液体外消化过程中，鳕鱼肝油、凤尾鱼、磷虾油和藻类油中丙二醛（MDA）、4-羟基-2-己烯醛（HHE）、4-羟基-2-壬烯醛（HNE）和 4-氧-2-壬烯醛（ONE）的形成。还研究了向鳕鱼肝油中添加兔胃脂肪酶、脂肪酶抑制剂（奥利司他）和生育酚对脂肪分解和氧化的影响。在海洋油中，鳕鱼肝油消化后检测到的醛水平最高（18µM MDA、3µM HHE 和 0.2µM HNE），而磷虾油和藻类油中的醛水平最低。兔胃脂肪酶的添加显著增加了 HNE 在消化过程中的释放。奥利司他显著降低了脂肪分解和 MDA 的形成。生育酚延迟了 MDA 和 HHE 的形成，Covi-ox® T 70 EU 混合生育酚比纯 α-生育酚更有效。
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