HIV 感染、艾滋病和抗逆转录病毒治疗对口、泪腺外分泌发病机制的影响。
Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.
机构信息
School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
出版信息
Int J Mol Sci. 2018 Sep 13;19(9):2747. doi: 10.3390/ijms19092747.
Abstract
The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced by pharmacotherapies directed at the infectious agents. Here, we briefly review the role of the salivary glands and lacrimal glands in normal physiology and exocrine pathogenesis within the context of HIV infection and acquired immune deficiency syndrome (AIDS), including the contribution of antiretroviral therapies on both. Subsequently, we discuss the impact of HIV infection and the types of antiretroviral therapy on disease management and therapy development efforts.
摘要
外分泌腺的结构和功能会受到人类免疫缺陷病毒 (HIV) 感染及其合并症的影响，包括先天和适应性免疫反应。同时，外分泌功能也可能受到针对感染因子的药物治疗的影响。在这里，我们简要回顾了唾液腺和泪腺在 HIV 感染和获得性免疫缺陷综合征 (AIDS) 背景下的正常生理学和外分泌发病机制中的作用，包括抗逆转录病毒疗法对此两者的影响。随后，我们讨论了 HIV 感染和抗逆转录病毒治疗类型对疾病管理和治疗开发工作的影响。
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