对超过 100 万人的基因分析确定了 535 个与血压特征相关的新基因座。
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
机构信息
Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
出版信息
Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17.
Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
摘要
高血压是一种高度遗传性和可改变的心血管疾病风险因素。我们报告了迄今为止在超过 100 万欧洲血统人群中进行的最大规模的血压特征（收缩压、舒张压和脉搏压）的遗传关联研究。我们确定了 535 个新的血压基因座，这些基因座不仅为血压调节提供了新的生物学见解，还突出了血压和生活方式暴露之间的共同遗传结构。我们的研究结果为血压调节提供了新的生物学途径，为未来更好地预防心血管疾病提供了潜力。
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