Lai Chi-Chih, Lin Pei-Wen, Lin Hsin-Ching, Friedman Michael, Chang Hsueh-Wen, Salapatas Anna M, Lin Meng-Chih, Huang Kuo-Tung
1 Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan.
2 Department of Ophthalmology, Division of Glaucoma, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan.
Ann Otol Rhinol Laryngol. 2018 Dec;127(12):912-918. doi: 10.1177/0003489418800089. Epub 2018 Sep 21.
: The aim of this study was to evaluate the effects of upper airway surgery on daytime sleepiness in nonobese patients with obstructive sleep apnea/hypopnea syndrome (OSA).
: This retrospective study included 121 consecutive adult nonobese patients with OSA from a tertiary academic medical center. Patients with OSA who refused continuous positive airway pressure therapy, or in whom it was unsuccessful, and then underwent OSA surgery were enrolled. Evaluations of excessive daytime sleepiness using the Epworth Sleepiness Scale (ESS) and major parameters of objective full-night polysomnography were collected preoperatively and at least 3 months postoperatively. Statistical analysis was performed using the Wilcoxon signed rank test and Wilcoxon rank sum test.
: When pre- and postoperative ESS and polysomnographic parameters were compared in all patients, ESS scores, apnea/hypopnea index, and snoring index showed statistically significant improvements ( P = .007, P < .001, and P < .001, respectively). When patients were classified into mild, moderate, and severe OSA groups, snoring index had statistically significant improvements in all 3 groups, and apnea/hypopnea index had statistically significant decreases in the moderate and severe OSA groups. Although reductions in ESS scores were found in all 3 groups, the most statistically significant improvement was noted only in the severe OSA group.
: OSA surgery can improve daytime sleepiness in nonobese patients with OSA, especially for patients with severe OSA. This study elucidates the effects of OSA surgery on daytime sleepiness by excluding the major confounding factor of obesity. This study adds to the literature on the effects of upper airway surgery for nonobese patients with OSA on daytime quality of life.
本研究旨在评估上气道手术对非肥胖阻塞性睡眠呼吸暂停/低通气综合征(OSA)患者日间嗜睡的影响。
这项回顾性研究纳入了来自一家三级学术医疗中心的121例连续的成年非肥胖OSA患者。纳入的患者为拒绝持续气道正压通气治疗或治疗失败后接受OSA手术的OSA患者。术前及术后至少3个月收集使用爱泼华嗜睡量表(ESS)评估的日间过度嗜睡情况以及全夜多导睡眠图的主要参数。采用Wilcoxon符号秩检验和Wilcoxon秩和检验进行统计分析。
在所有患者中比较术前和术后的ESS及多导睡眠图参数时,ESS评分、呼吸暂停/低通气指数和打鼾指数均有统计学意义的改善(分别为P = 0.007、P < 0.001和P < 0.001)。当将患者分为轻度、中度和重度OSA组时,打鼾指数在所有3组中均有统计学意义的改善,呼吸暂停/低通气指数在中度和重度OSA组中有统计学意义的降低。虽然在所有3组中均发现ESS评分有所降低,但仅在重度OSA组中观察到最具统计学意义的改善。
OSA手术可改善非肥胖OSA患者的日间嗜睡,尤其是重度OSA患者。本研究通过排除肥胖这一主要混杂因素,阐明了OSA手术对日间嗜睡的影响。本研究补充了关于上气道手术对非肥胖OSA患者日间生活质量影响的文献。