体液中的外泌体miR-1246是胃肠道癌症的潜在生物标志物。

Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer.

作者信息

Wei Chunmeng, Li Yasi, Huang Kaiming, Li Gang, He Min

机构信息

School of Public Health, Guangxi Medical University, Nanning 530021, PR China.

College of Arts & Sciences, Stony Brook University, NY 11790, USA.

出版信息

Biomark Med. 2018 Oct;12(10):1185-1196. doi: 10.2217/bmm-2017-0440. Epub 2018 Sep 21.

DOI:10.2217/bmm-2017-0440

PMID:30235938

Abstract

AIM

The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer.

METHODS

A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed.

RESULTS

A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively.

CONCLUSION

Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.

摘要

目的

旨在系统评估外泌体微小RNA（miRNA）是否可被视为胃肠道癌诊断的潜在微创生物标志物。

方法

对胃肠道癌中外泌体miRNA表达进行系统评价和荟萃分析。

结果

从PubMed和EMBASE数据库共检索到370篇文章。绘制了三种miRNA（miR-21、miR-1246和miR-4644）的汇总受试者工作特征曲线，miR-21、miR-1246和miR-4644的敏感性分别为0.66、0.920和0.750；特异性分别为0.87、0.958和0.769；区分胃肠道癌患者与对照受试者的曲线下面积分别为0.876、0.969和0.827。