arrestins 和 G 蛋白在细胞信号转导中的作用：一枚硬币有两面。
Arrestins and G proteins in cellular signaling: The coin has two sides.
机构信息
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
出版信息
Sci Signal. 2018 Sep 25;11(549):eaav1646. doi: 10.1126/scisignal.aav1646.
Abstract
Several studies have suggested that arrestin-mediated signaling by GPCRs requires G protein activation; however, in this issue of , Luttrell documented arrestin-dependent activation of ERK1/2 by a number of GPCRs. These studies do not contradict each other, but illustrate the complexity of cellular signaling that cannot and should not be reduced to simplistic models.
摘要
一些研究表明，GPCR 介导的 arrestin 信号需要 G 蛋白激活；然而，在本期 中，Luttrell 记录了许多 GPCR 通过 arrestin 依赖性激活 ERK1/2。这些研究并不相互矛盾，而是说明了细胞信号的复杂性，不能也不应该简化为简单的模型。
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