人乳头瘤病毒在外阴癌中的流行情况及其预后价值：系统评价和荟萃分析。
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis.
机构信息
Department of Obstetrics and Gynecology, Capital Medical University affiliated Beijing Chaoyang Hospital, Chaoyang District, Beijing, PR. China.
出版信息
PLoS One. 2018 Sep 26;13(9):e0204162. doi: 10.1371/journal.pone.0204162. eCollection 2018.
The purpose of this study was to estimate the prevalence of human papillomavirus (HPV) in vulvar cancer and determine whether positive HPV in vulvar cancer was associated with a better prognosis. Literature searches of Ovid EMBASE, PubMed, Web of Science and Cochrane Library were performed to identify related studies published from January 2000 to May 2017. A total of 33 studies including 7,721 subjects were selected in this meta-analysis. Overall, the HPV prevalence in vulvar cancer tissue was 34% (95% CI: 28%-39%) with 45% (95% CI: 28%-64%) in Asian populations and 34% (95% CI: 26%-42%) in Caucasian populations. The HPV-positive vulvar cancer was associated with better overall survival (hazard ratio = 0.64, 95% CI: 0.47-0.87; P = 0.004) and recurrence-free survival (hazard ratio = 0.66, 95% CI: 0.45-0.97; P = 0.03) compared with HPV-negative counterpart. HPV status may play an important role in predicting the prognosis of patients with vulvar cancer. The HPV-positive vulvar cancer women might relatively have a better survival than HPV-negative ones.
本研究旨在评估人乳头瘤病毒（HPV）在外阴癌中的流行情况，并确定外阴癌中 HPV 阳性是否与更好的预后相关。通过对 Ovid EMBASE、PubMed、Web of Science 和 Cochrane Library 进行文献检索，以确定从 2000 年 1 月至 2017 年 5 月发表的相关研究。这项荟萃分析共纳入了 33 项研究，共计 7721 例患者。总体而言，外阴癌组织中 HPV 的流行率为 34%（95%CI：28%-39%），亚洲人群中 HPV 的流行率为 45%（95%CI：28%-64%），白种人群中 HPV 的流行率为 34%（95%CI：26%-42%）。HPV 阳性外阴癌患者的总生存率（风险比=0.64，95%CI：0.47-0.87；P=0.004）和无复发生存率（风险比=0.66，95%CI：0.45-0.97；P=0.03）均优于 HPV 阴性患者。HPV 状态在外阴癌患者的预后预测中可能发挥重要作用。HPV 阳性外阴癌患者的生存情况可能优于 HPV 阴性患者。
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