三阴性乳腺癌中的CD11c阳性树突状细胞
CD11c-Positive Dendritic Cells in Triple-negative Breast Cancer.
作者信息
Lee Heejae, Lee Hee Jin, Song In Hye, Bang Won Seon, Heo Sun-Hee, Gong Gyungyub, Park In Ah
机构信息
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Asan Center for Cancer Genome Discovery - Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
出版信息
In Vivo. 2018 Nov-Dec;32(6):1561-1569. doi: 10.21873/invivo.11415.
BACKGROUND
Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are prognostic markers in triple-negative breast cancer (TNBC). Our study analyzed the relationship between cluster of differentiation (CD)11c-positive dendritic cells (DCs) and TILs and TLSs to elucidate mechanisms of TIL influx.
MATERIALS AND METHODS
Immunohistochemical staining for CD4, CD8, and CD11c in tissue microarrays from 681 patients with TNBC was performed. The proportions of TILs and TLSs were reviewed. Two additional TNBC gene expression datasets were used.
RESULTS
CD11c expression showed a significantly positive correlation with the level of TILs and the number of CD4 and CD8 T-cells, as well as an abundance of TLSs. CD11C gene expression was also significantly correlated with expression of CD4, CD8, and genes related to TLSs in both datasets.
CONCLUSION
We demonstrated a strong correlation of CD11c expression, which represents DCs, with TILs and TLSs in TNBC. Further investigation is warranted to identify therapeutic modalities that facilitate recruitment and activation of DCs.
背景
肿瘤浸润淋巴细胞（TILs）和三级淋巴结构（TLSs）是三阴性乳腺癌（TNBC）的预后标志物。我们的研究分析了分化簇（CD）11c阳性树突状细胞（DCs）与TILs和TLSs之间的关系，以阐明TIL流入的机制。
材料与方法
对681例TNBC患者组织芯片进行CD4、CD8和CD11c免疫组化染色。回顾TILs和TLSs的比例。使用另外两个TNBC基因表达数据集。
结果
CD11c表达与TILs水平、CD4和CD8 T细胞数量以及TLSs丰度呈显著正相关。在两个数据集中，CD11C基因表达也与CD4、CD8以及与TLSs相关的基因表达显著相关。
结论
我们证明了代表DCs的CD11c表达与TNBC中的TILs和TLSs密切相关。有必要进一步研究以确定促进DCs募集和激活的治疗方式。
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