囊性纤维化患者的运动试验——通气参数的重要性。
Exercise testing in patients with cystic fibrosis-importance of ventilatory parameters.
机构信息
Georgia Prevention Institute, Augusta University, 1120 15th Street, HS-1725, Augusta, GA, 30912, USA.
Pediatric Pulmonology, Augusta University, Augusta, GA, USA.
出版信息
Eur J Appl Physiol. 2019 Jan;119(1):227-234. doi: 10.1007/s00421-018-4018-5. Epub 2018 Oct 24.
BACKGROUND
Ventilatory parameters obtained during exercise predict survival in several chronic diseases; however, long-term changes in exercise ventilatory parameters in patients with cystic fibrosis (CF) have yet to be examined and potential differences between sexes in CF are unknown.
PURPOSE
We sought to examine the change in exercise ventilatory parameters over time in patients with CF and determine if the change is different between sexes.
METHODS
Exercise capacity (VO peak) and exercise ventilatory parameters (V/VO peak, V/VCO peak, and V/VCO slope) were determined from a maximal cardio-pulmonary test on a cycle ergometer on two visits separated by 39 ± 16 months in 20 patients with CF (10 female, 10 male).
RESULTS
No differences between sexes were observed at visit 1 (all p > 0.05). Overall, exercise ventilatory parameters significantly (p < 0.05) deteriorated between visits, with no change (p > 0.05) in VO peak. Moreover, compared to males, female patients exhibited greater deteriorations in V/VO peak (p = 0.001), V/VCO peak (p = 0.002), and V/VCO slope (p = 0.016) between visits.
CONCLUSIONS
These data in patients with CF indicate that exercise ventilatory parameters decline over time despite no change in VO peak, and female patients exhibit a more rapid deterioration compared to males.
背景
在几种慢性疾病中，运动时获得的通气参数可预测生存率；然而，囊性纤维化 (CF) 患者的运动通气参数的长期变化尚未被研究，CF 患者中性别间的潜在差异也尚不清楚。
目的
我们旨在研究 CF 患者随时间推移运动通气参数的变化，并确定这些变化在性别间是否存在差异。
方法
在两次相隔 39±16 个月的就诊中，对 20 名 CF 患者（10 名女性，10 名男性）进行了一次最大心肺测试，使用测功计进行了运动能力（VO 峰值）和运动通气参数（V/VO 峰值、V/VCO 峰值和 V/VCO 斜率）的测定。
结果
在第一次就诊时，男女之间没有差异（均 P＞0.05）。总体而言，运动通气参数在两次就诊之间明显恶化（均 P＜0.05），而 VO 峰值没有变化（P＞0.05）。此外，与男性相比，女性患者的 V/VO 峰值（P＝0.001）、V/VCO 峰值（P＝0.002）和 V/VCO 斜率（P＝0.016）恶化更明显。
结论
这些 CF 患者的数据表明，尽管 VO 峰值没有变化，但运动通气参数随时间推移会下降，而且女性患者的恶化速度比男性更快。
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