建立并验证了一种用于分析聚对苯二甲酸乙二醇酯中双酚 A 的 LC-MS/MS 方法。
Development and validation of a LC-MS/MS method for the analysis of bisphenol a in polyethylene terephthalate.
机构信息
Department of Analytical Chemistry, I3A, University of Zaragoza, Campus Rio Ebro, C. Maria de Luna 3, 50018 Zaragoza, Spain; Department of Agro-Food, Environmental and Animal Sciences, University of Udine, Via Sondrio 2/A, 33100 Udine, Italy.
Department of Analytical Chemistry, I3A, University of Zaragoza, Campus Rio Ebro, C. Maria de Luna 3, 50018 Zaragoza, Spain.
出版信息
Food Chem. 2019 Feb 15;274:246-253. doi: 10.1016/j.foodchem.2018.08.109. Epub 2018 Aug 25.
Bisphenol A (BPA) is widely recognized being an endocrine disrupter and it is employed in many food packaging applications. Although it is not intended to take part in the manufacture of polyethylene terephthalate (PET) food grade, the presence of BPA in recycled PET should not be neglected. To satisfy the increasing need to ensure "BPA-free" articles, a liquid chromatography-tandem mass spectrometry method was developed. The crucial step in the sample preparation was the total dissolution/reprecipitation of the polymer. The repeatability of the method (RSD%, n = 6) was lower than 7.6%, while HorRat values ranged between 0.3 and 0.5. Limits of detection and quantitation were 1.0 and 3.3 ng g, respectively. Recovery ranged from 89 to 107%. The method was applied to 23 samples of virgin and recycled pellets, preforms and bottles. Migration tests were also carried out. Results shown significantly higher levels of BPA in recycled PET.
双酚 A（BPA）被广泛认为是一种内分泌干扰物，它被应用于许多食品包装应用中。尽管它不是用于制造聚对苯二甲酸乙二醇酯（PET）食品级别的，但不应忽视回收 PET 中存在的 BPA。为了满足日益增长的确保“无 BPA”物品的需求，开发了一种液相色谱-串联质谱法。样品制备的关键步骤是聚合物的完全溶解/再沉淀。该方法的重复性（RSD%，n=6）低于 7.6%，而 HorRat 值在 0.3 到 0.5 之间。检测限和定量限分别为 1.0 和 3.3ng/g。回收率在 89%到 107%之间。该方法应用于 23 个原始和回收颗粒、预成型件和瓶子的样品。还进行了迁移测试。结果显示，回收 PET 中的 BPA 水平明显更高。
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