采用无标记方法评价阿尔茨海默病淀粉样纤维的光降解。
Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach.
机构信息
Institute for Advanced Materials, Jiangsu University, China.
出版信息
Chem Commun (Camb). 2018 Nov 20;54(93):13084-13087. doi: 10.1039/c8cc07164k.
Abstract
Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).
摘要
淀粉样蛋白-β（Aβ）聚集体的降解已被认为是一种有吸引力的治疗和预防阿尔茨海默病（AD）的策略。然而，目前仍然缺乏一种原位、实时、无标记的技术来了解 Aβ 聚集体的降解过程。在这项工作中，我们开发了一种新方法，通过石英晶体微天平（QCM）在紫外光照射下用光敏的间-四（4-磺酸钠苯基）卟啉定量评估 Aβ 原纤维的降解。
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