精准行为医学：基因和基因组发现对行为体重减轻治疗的影响。
Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment.
机构信息
Weight Control and Diabetes Research Center, Department of Psychiatry and Human Behavior, The Miriam Hospital.
出版信息
Am Psychol. 2018 Nov;73(8):1045-1055. doi: 10.1037/amp0000253.
Abstract
This article reviews the concept of precision behavioral medicine and the progress toward applying genetics and genomics as tools to optimize weight management intervention. We discuss genetic, epigenetic, and genomic markers, as well as interactions between genetics and the environment as they relate to obesity and behavioral weight loss to date. Recommendations for the conditions under which genetics and genomics could be incorporated to support clinical decision-making in behavioral weight loss are outlined and illustrative scenarios of how this approach could improve clinical outcomes are provided. It is concluded that there is not yet sufficient evidence to leverage genetics or genomics to aid the treatment of obesity but the foundations are being laid. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
摘要
本文回顾了精准行为医学的概念，并探讨了将遗传学和基因组学作为工具应用于优化体重管理干预的进展。我们讨论了迄今为止与肥胖和行为性体重减轻相关的遗传、表观遗传和基因组标记，以及遗传与环境之间的相互作用。本文还概述了在何种条件下可以将遗传学和基因组学纳入以支持行为性体重减轻的临床决策，并提供了如何采用这种方法改善临床结果的示例。结论是，目前尚无足够证据利用遗传学或基因组学来辅助肥胖治疗，但相关基础正在奠定之中。（APA，2018，所有权利保留）。
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本文引用的文献
1
Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women.
Sci Rep. 2017 Sep 20;7(1):11955. doi: 10.1038/s41598-017-12109-9.
2
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
Nat Med. 2017 Jul;23(7):859-868. doi: 10.1038/nm.4358. Epub 2017 Jun 19.
3
Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review.
Obes Rev. 2017 Aug;18(8):832-851. doi: 10.1111/obr.12541. Epub 2017 May 19.
4
A systematic review of studies of DNA methylation in the context of a weight loss intervention.
Epigenomics. 2017 May;9(5):769-787. doi: 10.2217/epi-2016-0182.
5
DNA methylation aberrancies as a guide for surveillance and treatment of human cancers.
Epigenetics. 2017 Jun 3;12(6):416-432. doi: 10.1080/15592294.2017.1311434. Epub 2017 Mar 30.
6
DNA methylation signatures in peripheral blood strongly predict all-cause mortality.
Nat Commun. 2017 Mar 17;8:14617. doi: 10.1038/ncomms14617.
7
Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?
Gastroenterology. 2017 May;152(7):1695-1706. doi: 10.1053/j.gastro.2017.01.054. Epub 2017 Feb 15.
8
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
Nature. 2017 Jan 5;541(7635):81-86. doi: 10.1038/nature20784. Epub 2016 Dec 21.
9
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.
Nat Commun. 2016 Sep 6;7:12724. doi: 10.1038/ncomms12724.
10
Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.
Psychosom Med. 2017 Feb/Mar;79(2):224-233. doi: 10.1097/PSY.0000000000000380.
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