miR-145 表达的调控机制及其在癌症转移中的功能重要性。

Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis.

机构信息

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Biomed Pharmacother. 2019 Jan;109:195-207. doi: 10.1016/j.biopha.2018.10.037. Epub 2018 Nov 2.

DOI:10.1016/j.biopha.2018.10.037

PMID:30396077

Abstract

MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play influential roles in tumorigenesis and cancer metastasis. The expression of tumor suppressor miR-145 is reduced in various cancer cell lines, containing both solid tumors and blood malignancies. However, the responsible mechanisms of its down-regulation are a complicated network. miR-145 is potentially able to inhbit tumor cell metastasis by targeting of multiple oncogenes, including MUC1, FSCN1, Vimentin, Cadherin, Fibronectin, Metadherin, GOLM1, ARF6, SMAD3, MMP11, Snail1, ZEB1/2, HIF-1α and Rock-1. This distinctive role of miR-145 in the regulation of metastasis-related gene expression may introduce miR-145 as an ideal candidate for controlling of cancer metastasis by miRNA replacement therapy. The present review aims to discuss the current understanding of the different aspects of molecular mechanisms of miR-145 regulation as well as its role in r metastasis regulation.

摘要

MicroRNAs 是基因表达和调控的转录后调节剂，在肿瘤发生和癌症转移中发挥着重要作用。肿瘤抑制因子 miR-145 在各种癌细胞系中的表达降低，包括实体瘤和血液恶性肿瘤。然而，其下调的负责机制是一个复杂的网络。miR-145 可能通过靶向多个癌基因来抑制肿瘤细胞转移，包括 MUC1、FSCN1、Vimentin、Cadherin、Fibronectin、Metadherin、GOLM1、ARF6、SMAD3、MMP11、Snail1、ZEB1/2、HIF-1α 和 Rock-1。miR-145 在调节转移相关基因表达方面的独特作用可能使其成为 miRNA 替代治疗控制癌症转移的理想候选物。本综述旨在讨论 miR-145 调节的不同方面的分子机制以及其在转移调节中的作用的当前理解。