……感染的流行病学、临床特征、耐药性及治疗情况
Epidemiology, clinical characteristics, resistance, and treatment of infections by .
作者信息
Cortegiani Andrea, Misseri Giovanni, Fasciana Teresa, Giammanco Anna, Giarratano Antonino, Chowdhary Anuradha
机构信息
1Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy, University of Palermo, Via del vespro 129, 90127 Palermo, Italy.
2Department of Sciences for Health Promotion and Mother and Child Care, University of Palermo, Palermo, Italy.
出版信息
J Intensive Care. 2018 Oct 29;6:69. doi: 10.1186/s40560-018-0342-4. eCollection 2018.
spp infections are a major cause of morbidity and mortality in critically ill patients. is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans species, result in difficult eradication and frequent therapeutic failures of infections. The aim of this review was to provide an updated and comprehensive report of the global spread of , focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies.
spp感染是重症患者发病和死亡的主要原因。是一种新兴的多重耐药真菌，正在全球迅速传播。自2009年首次报告以来，五大洲的许多分离株已被鉴定为医院相关感染的病原体。独立且同时发生的疫情正成为医疗保健和科学界的主要担忧。此外，实验室错误鉴定和多重耐药谱在其他非白色念珠菌物种中很少见，导致spp感染难以根除且治疗失败频繁。本综述的目的是提供一份关于spp全球传播的最新综合报告，重点关注临床和微生物学特征、毒力和抗真菌耐药机制，以及现有控制、预防和治疗策略的疗效。
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