儿童、青少年及青年黑色素瘤：426例病例的解剖临床特征及预后研究

Melanoma in children, adolescents and young adults: anatomo-clinical features and prognostic study on 426 cases.

作者信息

Bagnoni Giovanni, Fidanzi Cristian, D'Erme Angelo Massimiliano, Viacava Paolo, Leoni Matteo, Strambi Silvia, Calani Chiara, Bertocchini Alessia, Morganti Riccardo, Spinelli Claudio

机构信息

Melanoma and Skin Cancer Unit AVNO (Area Vasta Nord Ovest) and Unit of Dermatology, Livorno Hospital, Livorno, Italy.

Unit of Pathology, Livorno Hospital, Livorno, Italy.

出版信息

Pediatr Surg Int. 2019 Jan;35(1):159-165. doi: 10.1007/s00383-018-4388-0. Epub 2018 Nov 8.

DOI:10.1007/s00383-018-4388-0

PMID:30411144

Abstract

PURPOSE

This study was conducted to determine the difference in anatomo-pathological and prognostic features of cutaneous melanoma in children, adolescents and young adults.

METHODS

This is a retrospective review on 383 young patients ≤ 39 years of age with cutaneous melanoma, in a period from 2006 to 2016 in Area Vasta Nord Ovest, Tuscany, Italy. We subdivided patients in three groups (children ≤ 14 years, adolescents 15-21 years, young adults 22-39 years). We correlated all the anatomo-pathological parameters with age groups.

RESULTS

We identified a total of 426 cases of cutaneous melanoma on an overall total of 383 patients. Mean age at diagnosis for all the patients ≤ 39 years of age was 31.2 years: in group A was 11.2 years, in group B 19.2 years and in group C 32.5 years. Incidence, in the subjects between 0 and 14 years, is 14 cases per million inhabitants, between 15 and 21 years of 145, and between 22 and 39 years of 394. Global incidence was 1.6 case per million for group A, 8.9 cases per million for group B, 105 cases per million for group C. No statistically significative correlation could be described for clinical parameters and age groups.

CONCLUSIONS

Incidence of melanoma in our casuistry results as the highest in the world. These data open new study for this kind of cancer.

摘要

目的

本研究旨在确定儿童、青少年和青年皮肤黑色素瘤在解剖病理学和预后特征方面的差异。

方法

这是一项对2006年至2016年期间意大利托斯卡纳大区西北广大地区383例年龄≤39岁的皮肤黑色素瘤年轻患者进行的回顾性研究。我们将患者分为三组（≤14岁的儿童、15 - 21岁的青少年、22 - 39岁的青年）。我们将所有解剖病理学参数与年龄组进行关联。

结果

在总共383例患者中，我们共识别出426例皮肤黑色素瘤病例。所有≤39岁患者的平均诊断年龄为31.2岁：A组为11.2岁，B组为19.2岁，C组为32.5岁。0至14岁人群的发病率为每百万居民14例，15至21岁为145例，22至39岁为394例。A组全球发病率为每百万1.6例，B组为每百万8.9例，C组为每百万105例。临床参数与年龄组之间未发现有统计学意义的相关性。