基于半导体聚合物的纳米粒子用于第二近红外窗口的光热治疗。
Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window.
机构信息
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China.
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China.
出版信息
Chem Commun (Camb). 2018 Dec 14;54(96):13599-13602. doi: 10.1039/c8cc07583b. Epub 2018 Nov 19.
We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability. Furthermore, our nanoparticles could be efficiently uptaken by cancer cells and exhibited outstanding anticancer ability both in vitro and in vivo under NIR-II laser irradiation.
我们设计了新型基于二酮吡咯并吡咯聚合物的纳米粒子（DPP-IID-FA），它在近红外光窗口中表现出强吸收和优异的光热转换性能，并且具有高生物相容性和光稳定性。此外，我们的纳米粒子能够被癌细胞有效摄取，并在近红外二区激光照射下表现出优异的体外和体内抗癌能力。
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