钯催化的多烯酸化学选择性脱羧反应
Palladium-Catalyzed Chemoselective Protodecarboxylation of Polyenoic Acids.
作者信息
Al-Huniti Mohammed H, Perez Mark A, Garr Matthew K, Croatt Mitchell P
机构信息
Department of Chemistry and Biochemistry , University of North Carolina at Greensboro , 435 Sullivan Science Building , Greensboro , North Carolina 27402 , United States.
出版信息
Org Lett. 2018 Dec 7;20(23):7375-7379. doi: 10.1021/acs.orglett.8b03016. Epub 2018 Nov 27.
Conditions for the first palladium-catalyzed chemoselective protodecarboxylation of polyenoic acids to give the desired polyenes in good yields are presented. The reactions proceed under mild conditions using either a Pd(0) or Pd(II) catalyst and tolerate a variety of aryl and aliphatic substitutions. Unique aspects of the reaction include the requirement of phosphines, water, and a polyene adjacent to the carboxylic acid.
本文介绍了首例钯催化多烯酸化学选择性脱羧反应的条件，该反应能以良好产率生成所需的多烯。反应在温和条件下进行，使用零价钯或二价钯催化剂，并且能耐受多种芳基和脂肪族取代基。该反应的独特之处包括对膦、水以及羧酸相邻多烯结构的要求。
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