住宅空气清洁干预对与室内半挥发性有机化合物相关的癌症风险的影响：一项综合模拟研究。
Effect of residential air cleaning interventions on risk of cancer associated with indoor semi-volatile organic compounds: a comprehensive simulation study.
机构信息
School of Architecture and Urban Planning, Nanjing University, Nanjing, Jiangsu, China; Department of Building Science, School of Architecture, Tsinghua University, Beijing, China; Nicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, NC, USA.
Department of Building Science, School of Architecture, Tsinghua University, Beijing, China; Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Tsinghua University, Beijing, China.
出版信息
Lancet Planet Health. 2018 Dec;2(12):e532-e539. doi: 10.1016/S2542-5196(18)30236-5.
BACKGROUND
Human exposure to multiphase semi-volatile organic compounds (SVOCs) via multiple routes has been associated with health risks. Residential air cleaning interventions remove SVOCs adsorbed on airborne particles, which subsequently affects indoor concentrations of SVOCs in other phases. We aimed to investigate the effect of residential air cleaning interventions on the overall cancer risk associated with multiphase SVOCs.
METHODS
We simulated concentrations of eight multiphase SVOCs (including seven polycyclic aromatic hydrocarbons [PAHs] and di(2-ethylhexyl) phthalate [DEHP]) using a kinetic partition mass balance model for three exposure scenarios: naturally ventilated residences without intervention (scenario 1), naturally ventilated residences with portable air purifiers (scenario 2), and mechanically ventilated residences with air filtration units (scenario 3). We converted indoor concentrations of the individual PAHs into indoor concentrations of equivalent benzo[a]pyrene (BaP) using the BaP cancer potency equivalent factor for each PAH. We estimated indoor exposure to SVOCs via inhalation, dermal absorption, and ingestion. For each scenario, we calculated the incremental lifetime cancer risk (ILCR) associated with indoor exposure to each SVOC via the three routes and the total ILCR (all three routes combined).
FINDINGS
Mean total ILCRs associated with exposure to BaP were 4·42 × 10 (SD 2·84) for scenario 1, 2·36 × 10 (1·53) for scenario 2, and 4·88 × 10 (4·86) for scenario 3. Mean total ILCRs associated with exposure to DEHP were 3·61 × 10 (3·60) for scenario 1, 7·51 × 10 (5·34) for scenario 2, and 1·48 × 10 (2·02) for scenario 3. Ingestion of settled dust was the most important contributor to the total ILCR for both BaP and DEHP in all the studied scenarios.
INTERPRETATION
The large-scale use of mechanical ventilation systems in urban residences in China needs to be evaluated owing to their potential exacerbation of the cancer risks associated with common indoor SVOCs.
FUNDING
National Key Project of the Ministry of Science and Technology and Natural Science Foundation of China.
背景
人类通过多种途径接触多相半挥发性有机化合物（SVOCs）与健康风险有关。住宅空气净化干预措施可去除吸附在空气传播颗粒上的 SVOCs，这随后会影响其他相态中 SVOCs 的室内浓度。我们旨在研究住宅空气净化干预对多相 SVOCs 相关整体癌症风险的影响。
方法
我们使用动力学分配质量平衡模型模拟了八种多相 SVOCs（包括七种多环芳烃[PAHs]和邻苯二甲酸二（2-乙基己基）酯[DEHP]）的浓度，共涉及三种暴露情况：无干预的自然通风住宅（情况 1）、配备便携式空气净化器的自然通风住宅（情况 2）和配备空气过滤装置的机械通风住宅（情况 3）。我们将各 PAH 的室内浓度转换为等效苯并[a]芘（BaP）的室内浓度，方法是为每个 PAH 使用 BaP 致癌潜能等效因子。我们通过吸入、皮肤吸收和摄入估算了 SVOCs 的室内暴露量。对于每种情况，我们通过三种途径计算了与室内 SVOCs 暴露相关的个体 SVOCs 的增量终生癌症风险（ILCR），以及三种途径的总和（所有三种途径的总和）。
结果
与 BaP 暴露相关的总平均 ILCR 分别为情况 1 中 4.42 × 10（SD 2.84），情况 2 中 2.36 × 10（1.53），情况 3 中 4.88 × 10（4.86）。与 DEHP 暴露相关的总平均 ILCR 分别为情况 1 中 3.61 × 10（3.60），情况 2 中 7.51 × 10（5.34），情况 3 中 1.48 × 10（2.02）。在所有研究情况下，沉降灰尘的摄入是 BaP 和 DEHP 总 ILCR 的最重要贡献者。
解释
由于机械通风系统可能会加剧与常见室内 SVOCs 相关的癌症风险，因此需要对中国城市住宅中大规模使用机械通风系统进行评估。
资金
科技部国家重点研发计划和国家自然科学基金。
Zotero 插件