The availability of the α7 nicotinic acetylcholine receptor in recent-onset psychosis: a study using F-ASEM PET.

Limited postmortem evidence suggests a diminished availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in hippocampus in psychosis. In this cross-sectional PET study, we used F-ASEM, a radiotracer targeting the α7-nAChR, with positron emission tomography to compare the binding of F-ASEM in hippocampus between individuals with recent-onset psychosis and healthy controls. Individuals with recent-onset psychosis [non-affective psychosis (NP) or affective psychosis], and particularly those with NP, showed lower hippocampal binding of F-ASEM than healthy controls. Among patients, lower binding was associated with lower performance in two cognitive domains after controlling for age. Low availability of the α7-nAChR in hippocampus may be linked to recent-onset of psychosis. Further study is needed to assess its clinical relationship to neuropsychiatric symptoms.