耐利奈唑胺鸟分枝杆菌复合群及脓肿分枝杆菌临床分离株中的基因突变
Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates.
作者信息
Kim Su-Young, Jhun Byung Woo, Moon Seong Mi, Jeon Kyeongman, Kwon O Jung, Huh Hee Jae, Lee Nam Yong, Shin Sung Jae, Daley Charles L, Koh Won-Jung
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
出版信息
Diagn Microbiol Infect Dis. 2019 May;94(1):38-40. doi: 10.1016/j.diagmicrobio.2018.10.022. Epub 2018 Nov 30.
There are no studies evaluating the mechanisms driving linezolid resistance in nontuberculous mycobacteria. The novel mutations G2599A and A2137T in the 23S rRNA gene and mutations A439G and G443A in the rplD gene associated with linezolid resistance were identified in linezolid-resistant M. avium complex isolates.
目前尚无评估非结核分枝杆菌中利奈唑胺耐药性驱动机制的研究。在耐利奈唑胺的鸟分枝杆菌复合群分离株中，鉴定出了与利奈唑胺耐药性相关的23S rRNA基因中的新突变G2599A和A2137T以及rplD基因中的突变A439G和G443A。
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