Y 染色体缺失与男性头颈部鳞状细胞癌不良预后的关联。
Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma.
机构信息
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom.
出版信息
Head Neck. 2019 Apr;41(4):993-1006. doi: 10.1002/hed.25537. Epub 2018 Dec 23.
BACKGROUND
Head and neck squamous cell carcinoma (HNSCC) is more prevalent in men than women and this disparity cannot be fully explained by known risk factors. Recent studies have shown that loss of Y chromosome (LoY) confers an increased risk of solid cancer and reduces life expectancy in men.
METHODS
Using publicly available data from The Cancer Genome Atlas, we investigated the prevalence of LoY and its association with clinicopathological features in male HNSCC.
RESULTS
LoY was detectable in around 25% of male HNSCC. Men with human papillomavirus-negative tumors exhibiting LoY experienced significantly worse overall survival than those with no LoY. Moreover, LoY tumors exhibited overexpression of genes involved in redox processes, including genes previously implicated in resistance to both radiotherapy and cisplatin-based chemotherapeutics.
CONCLUSION
LoY may be an indicator of poor prognosis in male HNSCC that is linked to the overexpression of genes associated with resistance to standard care therapies.
背景
头颈部鳞状细胞癌（HNSCC）在男性中的发病率高于女性，而这一差异不能完全用已知的风险因素来解释。最近的研究表明，Y 染色体丢失（LoY）会增加男性患实体癌的风险并降低预期寿命。
方法
我们使用来自癌症基因组图谱（TCGA）的公开可用数据，研究了 LoY 在男性 HNSCC 中的发生率及其与临床病理特征的关系。
结果
LoY 可在约 25%的男性 HNSCC 中检测到。HPV 阴性肿瘤中存在 LoY 的男性患者的总生存率明显低于不存在 LoY 的患者。此外，LoY 肿瘤表现出与氧化还原过程相关的基因过度表达，包括先前与放疗和顺铂为基础的化疗药物耐药性相关的基因。
结论
LoY 可能是男性 HNSCC 预后不良的一个指标，与与标准治疗方法耐药相关的基因过表达有关。
Zotero 插件