三阴性乳腺癌中pre-mir-34a rs72631823单核苷酸多态性的评估：一项病例对照研究。
Evaluation of pre-mir-34a rs72631823 single nucleotide polymorphism in triple negative breast cancer: A case-control study.
作者信息
Kalapanida Despoina, Zagouri Flora, Gazouli Maria, Zografos Eleni, Dimitrakakis Constantine, Marinopoulos Spyridon, Giannos Aris, Sergentanis Theodoros N, Kastritis Efstathios, Terpos Evangelos, Dimopoulos Meletios-Athanasios
机构信息
Department of Clinical Therapeutics, Alexandra Hospital, Medical School, University of Athens, Athens, Greece.
Department of Basic Medical Sciences, Laboratory of Biology, University of Athens School of Medicine, Athens, Greece.
出版信息
Oncotarget. 2018 Dec 11;9(97):36906-36913. doi: 10.18632/oncotarget.26385.
AIM
The purpose of this study is to evaluate the role of pre-miR34a rs72631823 as potential risk factor and/or prognostic marker in patients with triple negative breast cancer.
METHODS
114 samples of DNA from paraffin embedded breast normal tissues of patients with triple negative breast cancer and 124 samples of healthy controls were collected and analyzed for pre-miR34a rs72631823 polymorphism.
RESULTS
Pre-miR34a rs72631823 A allele was associated with increased TNBC risk both in univariate and multivariate analysis. The number of pre-miR34a rs72631823 AA subjects was very small and the association did not reach significance ( = 0.176, Fisher's exact test). The examined polymorphism was not associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR = 1.60, 95%CI: 0.64-3.96 for miR34 rs72631823 GA/AA vs. GG).
CONCLUSION
Our case-control study suggests that pre-miR34a rs72631823 A allele is associated with increased triple negative breast cancer risk.
目的
本研究旨在评估前体微小RNA34a rs72631823作为三阴性乳腺癌患者潜在风险因素和/或预后标志物的作用。
方法
收集114例三阴性乳腺癌患者石蜡包埋乳腺正常组织的DNA样本和124例健康对照样本，分析前体微小RNA34a rs72631823多态性。
结果
在单因素和多因素分析中，前体微小RNA34a rs72631823 A等位基因均与三阴性乳腺癌风险增加相关。前体微小RNA34a rs72631823 AA基因型的受试者数量非常少，该关联未达到显著水平（P = 0.176，Fisher精确检验）。在单因素或多因素Cox回归分析中，所检测的多态性与总生存期无关（对于微小RNA34 rs72631823 GA/AA与GG，校正风险比= 1.60，95%置信区间：0.64 - 3.96）。
结论
我们的病例对照研究表明，前体微小RNA34a rs72631823 A等位基因与三阴性乳腺癌风险增加相关。
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