一种用于估算人血浆中胆固醇酯转移蛋白（CETP）甘油三酯通量的数学模型。
A mathematical model to estimate cholesterylester transfer protein (CETP) triglycerides flux in human plasma.
作者信息
Jansen Martin, Puetz Gerhard, Hoffmann Michael M, Winkler Karl
机构信息
Institute of Clinical Chemistry and Laboratory Medicine, Medical Centre - University of Freiburg, Freiburg im Breisgau, Germany.
Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
出版信息
BMC Syst Biol. 2019 Jan 22;13(1):12. doi: 10.1186/s12918-019-0679-x.
BACKGROUND
Cholesterylester transfer protein (CETP) modulates the composition of various lipoproteins associated with cardiovascular disease. Despite its central role in lipoprotein metabolism, its mode of action is still not fully understood. Here we present a simple way to estimate CETP-mediated lipid fluxes between different lipoprotein fractions.
RESULTS
The model derived adequately describes the observed findings, especially regarding low- and high dense lipoproteins (LDL and HDL), delivering correlation coefficients of R = 0.567 (p < 0.001) and R = 0.466 (p < 0.001), respectively. These estimated fluxes correlate best among all other measured concentrations and 'lipid per lipoprotein' ratios to the observed fluxes.
CONCLUSION
Our model approach is independent of CETP-action's exact mechanistic mode. It is simple and easy to apply, and may be a useful tool in revealing CETP's ambiguous role in lipid metabolism. The model mirrors a diffusion-like exchange of triglycerides between lipoproteins. Cholesteryl ester and triglyceride concentrations measured in HDL, LDL and VLDL are sufficient to apply the model on a plasma sample.
背景
胆固醇酯转运蛋白（CETP）调节与心血管疾病相关的各种脂蛋白的组成。尽管其在脂蛋白代谢中起核心作用，但其作用方式仍未完全了解。在此，我们提出一种简单的方法来估计CETP介导的不同脂蛋白组分之间的脂质通量。
结果
所推导的模型充分描述了观察到的结果，特别是关于低密度脂蛋白和高密度脂蛋白（LDL和HDL），相关系数分别为R = 0.567（p <0.001）和R = 0.466（p <0.001）。在所有其他测量浓度和“每脂蛋白脂质”比率中，这些估计的通量与观察到的通量之间的相关性最佳。
结论
我们的模型方法独立于CETP作用的确切机制模式。它简单易应用，可能是揭示CETP在脂质代谢中模糊作用的有用工具。该模型反映了脂蛋白之间甘油三酯的类似扩散的交换。在HDL、LDL和VLDL中测量的胆固醇酯和甘油三酯浓度足以将该模型应用于血浆样本。
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