猪圆环病毒 2 型与其他猪病毒的混合感染。
Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses.
机构信息
Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
College of Life Sciences, Shandong Normal University, Jinan 250014, China.
出版信息
Viruses. 2019 Feb 21;11(2):185. doi: 10.3390/v11020185.
Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication of other pathogens. However, the exact mechanisms of PCVD/PCVAD are currently unknown. To date, many studies have reported that several cofactors, such as other swine viruses or bacteria, vaccination failure, and stress or crowding, in combination with PCV2, lead to PCVD/PCVAD. Among these cofactors, co-infection of PCV2 with other viruses, such as porcine reproductive and respiratory syndrome virus, porcine parvovirus, swine influenza virus and classical swine fever virus have been widely studied for decades. In this review, we focus on the current state of knowledge regarding swine co-infection with different PCV2 genotypes or strains, as well as with PCV2 and other swine viruses.
猪圆环病毒 2 型（PCV2）是引起猪圆环病毒病和猪圆环病毒相关疾病（PCVD/PCVAD）的病原体，存在于世界上每个主要的养猪国家。PCV2 感染可能下调宿主免疫系统，并增强其他病原体的感染和复制。然而，PCVD/PCVAD 的确切机制目前尚不清楚。迄今为止，许多研究报告称，几种伴随因子，如其他猪病毒或细菌、疫苗接种失败以及应激或拥挤，与 PCV2 共同作用导致 PCVD/PCVAD。在这些伴随因子中，PCV2 与其他病毒（如猪繁殖与呼吸综合征病毒、猪细小病毒、猪流感病毒和古典猪瘟病毒）的共同感染已被广泛研究了几十年。在这篇综述中，我们重点介绍了关于不同基因型或毒株的 PCV2 与其他猪病毒以及 PCV2 与其他猪病毒共同感染的最新知识状况。
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