Ophthalmic Research Group, Aston University, Birmingham, United Kingdom.
Children's University Hospital, University College Dublin and Dublin Institute of Technology, Dublin, Ireland.
Invest Ophthalmol Vis Sci. 2019 Feb 28;60(3):M1-M19. doi: 10.1167/iovs.18-25980.
With the growing prevalence of myopia, already at epidemic levels in some countries, there is an urgent need for new management approaches. However, with the increasing number of research publications on the topic of myopia control, there is also a clear necessity for agreement and guidance on key issues, including on how myopia should be defined and how interventions, validated by well-conducted clinical trials, should be appropriately and ethically applied. The International Myopia Institute (IMI) reports the critical review and synthesis of the research evidence to date, from animal models, genetics, clinical studies, and randomized controlled trials, by more than 85 multidisciplinary experts in the field, as the basis for the recommendations contained therein. As background to the need for myopia control, the risk factors for myopia onset and progression are reviewed. The seven generated reports are summarized: (1) Defining and Classifying Myopia, (2) Experimental Models of Emmetropization and Myopia, (3) Myopia Genetics, (4) Interventions for Myopia Onset and Progression, (5) Clinical Myopia Control Trials and Instrumentation, (6) Industry Guidelines and Ethical Considerations for Myopia Control, and (7) Clinical Myopia Management Guidelines.
随着近视的患病率不断上升,在一些国家已经达到流行程度,因此迫切需要新的管理方法。然而,随着关于近视控制主题的研究出版物数量不断增加,也非常有必要就关键问题达成共识和指导,包括如何定义近视以及如何适当和合乎道德地应用经过良好临床试验验证的干预措施。国际近视研究所(IMI)报告了迄今为止对动物模型、遗传学、临床研究和随机对照试验的研究证据进行的关键审查和综合,由该领域的 85 多名多学科专家进行,作为其中包含的建议的基础。作为近视控制必要性的背景,回顾了近视发病和进展的危险因素。生成的七个报告概述如下:(1)定义和分类近视,(2)正视化和近视的实验模型,(3)近视遗传学,(4)近视发病和进展的干预措施,(5)临床近视控制试验和仪器,(6)近视控制的行业准则和伦理考虑,以及(7)临床近视管理指南。