在专门的肌肉中发现的古老的肌球蛋白。
The ancient sarcomeric myosins found in specialized muscles.
机构信息
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA.
BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
出版信息
Skelet Muscle. 2019 Mar 5;9(1):7. doi: 10.1186/s13395-019-0192-3.
Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle. The sarcomeric myosin heavy chain (MYH) genes expressed in the major cardiac and skeletal muscles have been studied for decades. However, three ancient myosins, MYH7b, MYH15, and MYH16, remained uncharacterized due to their unique expression patterns in common mammalian model organisms and due to their relatively recent discovery in these genomes. This article reviews the literature surrounding these three ancient sarcomeric myosins and the specialized muscles in which they are expressed. Further study of these ancient myosins and how they contribute to the functions of the specialized muscles may provide novel insight into the history of striated muscle evolution.
横纹肌表达一系列肌球蛋白马达，这些马达经过调整以完成特定的任务。肌肉纤维中发现的每种肌球蛋白同工型都赋予纤维独特的收缩特性，以满足肌肉的需求。几十年来，人们一直在研究主要在心脏和骨骼肌肉中表达的肌球蛋白重链（MYH）基因。然而，由于它们在常见的哺乳动物模式生物中的独特表达模式以及在这些基因组中相对较新的发现，三种古老的肌球蛋白（MYH7b、MYH15 和 MYH16）仍未得到表征。本文回顾了围绕这三种古老的肌球蛋白和它们在其中表达的专门肌肉的文献。进一步研究这些古老的肌球蛋白以及它们如何有助于专门肌肉的功能，可能为横纹肌进化的历史提供新的见解。
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