左旋多巴对帕金森病言语不流畅的影响。
Effect of Levodopa on Speech Dysfluency in Parkinson's Disease.
作者信息
Im Hannah, Adams Scott, Abeyesekera Anita, Pieterman Marcus, Gilmore Greydon, Jog Mandar
机构信息
School of Communication Sciences and Disorders, Western University, Elborn College 1201 Western Road, London ON Canada N6G 1H1.
Health and Rehabilitation Sciences, Western University, Elborn College 1201 Western Road, London ON Canada N6G 1H1.
出版信息
Mov Disord Clin Pract. 2018 Dec 30;6(2):150-154. doi: 10.1002/mdc3.12714. eCollection 2019 Feb.
OBJECTIVE
To examine the effect of levodopa medication on speech dysfluency in Parkinson's disease.
METHODS
Fifty-one individuals with Parkinson's disease (IWPD) read aloud during and medication states. Total speech dysfluencies were calculated from transcriptions of recorded speech samples.
RESULTS
Severity of speech dysfluency was not significantly related to the severity of motor symptoms, duration of disease, levodopa equivalent dosage, or age. When the IWPD were divided into two groups based on dysfluency severity, there was a significant group-by-medication state interaction. There was a significant correlation between the medication-related change in speech dysfluency and the -medication severity of speech dysfluency measure (r = -0.46).
CONCLUSIONS
The results of this study indicate that levodopa medication can have a significant effect on speech dysfluency. The beneficial levodopa effect appears to be related to the severity of the medication speech dysfluency. Results did not provide strong support for the excess dopamine theory of stuttering in IWPD. A dualistic model of the effects of dopamine on speech fluency in PD is proposed.
目的
研究左旋多巴药物治疗对帕金森病言语不流畅的影响。
方法
51名帕金森病患者（IWPD）在服药和未服药状态下大声朗读。根据录制的语音样本转录计算总的言语不流畅情况。
结果
言语不流畅的严重程度与运动症状的严重程度、病程、左旋多巴等效剂量或年龄无显著相关性。当根据不流畅严重程度将IWPD分为两组时，存在显著的组×服药状态交互作用。言语不流畅的药物相关变化与言语不流畅测量的服药后严重程度之间存在显著相关性（r = -0.46）。
结论
本研究结果表明，左旋多巴药物治疗可对言语不流畅产生显著影响。左旋多巴的有益作用似乎与药物性言语不流畅的严重程度有关。结果未为IWPD口吃的多巴胺过量理论提供有力支持。提出了多巴胺对PD言语流畅性影响的二元模型。
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