铜催化自由基接力实现苄位 C-H 键的对映选择性芳基化反应。
Enantioselective Arylation of Benzylic C-H Bonds by Copper-Catalyzed Radical Relay.
机构信息
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
出版信息
Angew Chem Int Ed Engl. 2019 May 6;58(19):6425-6429. doi: 10.1002/anie.201902191. Epub 2019 Apr 3.
A novel enantioselective copper-catalyzed arylation of benzylic C-H bonds, using alkylarenes as a limiting reagent, has been developed. A chiral bisoxazoline ligand bearing an acetate ester moiety plays a key role in both the reactivity and enantioselectivity of the reaction. The reaction provides efficient access to various chiral 1,1-diarylalkanes in good yields with good to excellent enantioselectivities, and displays excellent functional-group tolerance.
发展了一种新型的对映选择性铜催化苄位 C-H 键芳基化反应，使用烷基芳烃作为限制试剂。一种带有醋酸酯部分的手性双恶唑啉配体在反应的活性和对映选择性中都起着关键作用。该反应以良好到优异的对映选择性，提供了高效合成各种手性 1,1-二芳基烷烃的方法，并且具有很好的官能团耐受性。
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