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从 中分离得到的一个新三萜和一个新黄酮苷及其抗炎活性。

A new triterpenoid and a new flavonoid glycoside isolated from and their anti-inflammatory activity.

机构信息

Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang, China.

The First Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

出版信息

Nat Prod Res. 2020 Dec;34(24):3492-3498. doi: 10.1080/14786419.2019.1582037. Epub 2019 Mar 19.

Abstract

This study to investigate chemical constituents from the aerial of led to the isolation of a new trierpenoid and a new flavonoid, namely 3β-hydroxy-cycloart-24-en-26-acetyloxy (), and 3, 3', 5'-trimethoxyl-myricetin 7-O-β-D-glucopyranoside () along with eight known compounds (-). Their structures were established by spectral data analyses (MS, 1D and 2D NMR), as well as by comparison of spectral data with those of the related known compounds. The 24-en-lanostane type triterpenoid with a cyclopropane ring ( and was firstly reported from this specie, which might be chemotaxonomic markers of this specie. In addition, compounds and were examined for their anti-inflammatory activity. Compounds and inhibited the NF B induction by 60.61% and 24.30%.

摘要

本研究从 led 的地上部分中分离得到了一个新的三萜和一个新的黄酮类化合物,即 3β-羟基-环阿尔泰-24-烯-26-乙酰氧基 ()和 3,3',5'-三甲氧基杨梅素 7-O-β-D-吡喃葡萄糖苷 (),以及八个已知化合物 (-)。它们的结构通过光谱数据分析(MS、1D 和 2D NMR)以及与相关已知化合物的光谱数据比较来确定。具有环丙烷环的 24-烯-羊毛甾烷型三萜 ()和 是首次从该种中报道的,这可能是该种的化学分类学标志物。此外,还测试了化合物 和 的抗炎活性。化合物 和 抑制了 NF-B 的诱导,抑制率分别为 60.61%和 24.30%。

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