Hodge Caitlin, Badgwell Brian D
Department of General Surgery, Abington Memorial Hospital, Abington, Pennsylvania.
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J Surg Oncol. 2019 Jul;120(1):67-73. doi: 10.1002/jso.25453. Epub 2019 Mar 22.
Malignant ascites (MA) carries a poor prognosis. It can have a significant impact on quality of life (QOL), with increasing abdominal distention, pain, and dyspnea. Diuretics typically do not work well for MA. Paracentesis is effective in providing temporary symptom relief but requires frequent repeat procedures. Options for durable symptom management include indwelling catheters, peritoneal ports, peritoneovenous shunts, intraperitoneal (i.p.) catumaxomab, and hyperthermic i.p. chemotherapy. These interventions do not necessarily improve overall survival but may improve QOL.
恶性腹水(MA)预后较差。它会对生活质量(QOL)产生重大影响,导致腹胀、疼痛和呼吸困难加重。利尿剂通常对MA效果不佳。腹腔穿刺术能有效提供临时症状缓解,但需要频繁重复操作。持久症状管理的选择包括留置导管、腹腔端口、腹膜静脉分流术、腹腔内(i.p.)注射卡妥索单抗和腹腔内热化疗。这些干预措施不一定能提高总体生存率,但可能改善生活质量。