Muschitz Christian, Kautzky-Willer Alexandra, Rauner Martina, Winhöfer-Stöckl Yvonne, Haschka Judith
Externe Lehre, Medizinische Universität Wien, Wien, Österreich.
II. Medizinische Abteilung, Krankenhaus der Barmherzigen Schwestern Wien, Stumpergasse 13, 1060, Wien, Österreich.
Wien Klin Wochenschr. 2019 May;131(Suppl 1):174-185. doi: 10.1007/s00508-019-1462-0.
Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. The identification and management of fracture risk in these patients remains challenging. This manuscript explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated areal bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (FRAX) in these patients. It further reviews the impact of diabetes drugs on bone tissue as well as the efficacy of osteoporosis treatments in this population. An algorithm for the identification and management of diabetic patients at increased fracture risk is proposed.
脆性骨折日益被认为是1型和2型糖尿病的一种并发症,其骨折风险会随着疾病持续时间和血糖控制不佳而增加。识别和管理这些患者的骨折风险仍然具有挑战性。本文探讨了糖尿病成年患者骨脆性的临床特征,并重点介绍了最近评估这些患者的骨面积密度(BMD)、骨微结构和材料特性、生化标志物以及骨折预测算法(FRAX)的研究。它还回顾了糖尿病药物对骨组织的影响以及该人群骨质疏松治疗的疗效。提出了一种识别和管理骨折风险增加的糖尿病患者的算法。