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80 岁及以上和 90 岁及以上老年人结肠镜检查和结直肠癌发病率:美国退伍军人全国性研究。

Colonoscopy and colorectal cancer rates among octogenarians and nonagenarians: nationwide study of US veterans.

机构信息

Department of Medicine, Albany Medical Center, Albany, NY 12208, USA,

Department of Geriatrics, VA Stratton Medical Center, Albany, NY 12208, USA.

出版信息

Clin Interv Aging. 2019 Mar 26;14:609-614. doi: 10.2147/CIA.S192497. eCollection 2019.

Abstract

BACKGROUND

According to Surveillance, Epidemiology and End Results (SEER) database, colorectal cancer (CRC) is the fourth most common type of cancer and second highest in cancer-related death after lung cancer. The SEER database is geographically limited, currently present in only 10-12 states. Though this gives a good approximation about the overall direction of CRC incidence and prevalence, we need more nationwide data to compare numbers. Furthermore, colonoscopies and CRC rates in the Veterans Affair (VA) geriatric population have not been studied.

OBJECTIVES AND METHODS

Our aim was to study the rate of colonoscopies and CRC in octogenarians and nonagenarians and to find the prevalence of CRC in this population. The goal was to obtain data in this subset of patients in order to further expand CRC screening guidelines. A retrospective data analysis was performed consisting of US male veterans who underwent colonoscopy in the VA Health Care System from 2000 to 2015.

RESULTS AND CONCLUSION

A total of 458,224 patients aged ≥80 years were identified from the database between years 2000 and 2015. This was divided into three groups of age 80-84 years (89,621 patients), 85-90 years (248,155 patients), and >90 years (120,448 patients). A total of 81,946 patients underwent colonoscopies of which 9,365 were diagnosed with CRC. There was a statistically significant linear increase in rate of colonoscopies with increase in age suggesting that these veterans who end up living to a higher age eventually get a colonoscopy for one reason or the other. The drop in CRC percentage and prevalence observed in age group 85-90 years is statistically different when compared to that in 80-84 years and >90 years groups; however, its clinical significance remains to be elucidated.

摘要

背景

根据监测、流行病学和最终结果(SEER)数据库,结直肠癌(CRC)是第四大常见癌症,仅次于肺癌,是癌症相关死亡的第二大原因。SEER 数据库在地理上是有限的,目前仅存在于 10-12 个州。尽管这很好地估计了 CRC 发病率和流行率的总体趋势,但我们需要更多的全国性数据来比较数字。此外,退伍军人事务部(VA)老年人群的结肠镜检查和 CRC 率尚未得到研究。

目的和方法

我们的目的是研究 80 岁以上和 90 岁以上人群的结肠镜检查和 CRC 发生率,并确定该人群中 CRC 的患病率。目的是为这部分患者获取数据,以进一步扩大 CRC 筛查指南。对 2000 年至 2015 年期间在美国退伍军人事务部医疗保健系统中接受结肠镜检查的男性退伍军人进行了回顾性数据分析。

结果和结论

从 2000 年至 2015 年的数据库中确定了 458224 名年龄≥80 岁的患者。这些患者分为 3 组,年龄为 80-84 岁(89621 例)、85-90 岁(248155 例)和>90 岁(120448 例)。共有 81946 名患者接受了结肠镜检查,其中 9365 例被诊断为 CRC。随着年龄的增长,结肠镜检查的比例呈线性显著增加,这表明这些最终活到更高年龄的退伍军人最终会因某种原因接受结肠镜检查。与 80-84 岁和>90 岁组相比,85-90 岁组 CRC 百分比和患病率的下降具有统计学意义,但临床意义仍有待阐明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/164d/6440444/cceef37b3833/cia-14-609Fig1.jpg

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