阐明疟原虫对宿主细胞的摄取。
Elucidating Host Cell Uptake by Malaria Parasites.
机构信息
Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Trends Parasitol. 2019 May;35(5):333-335. doi: 10.1016/j.pt.2019.03.005. Epub 2019 Apr 16.
PMID:31003757
Abstract
The malaria parasite must digest host cytoplasm for normal growth, and many studies have revealed the essential role of proteases in hemoglobin digestion. Here, we discuss the results of Jonscher et al. (Cell Host Microbe 2019;25:166-173) who have, for the first time, identified a molecule, VPS45, involved in the uptake and trafficking of host cytoplasm to the digestive vacuole.
摘要
疟原虫必须消化宿主细胞质才能正常生长，许多研究揭示了蛋白酶在血红蛋白消化中的重要作用。在这里，我们讨论 Jonscher 等人的研究结果（Cell Host Microbe 2019；25：166-173），他们首次鉴定出一种参与宿主细胞质摄取和运输到消化液泡的分子 VPS45。
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