香豆素基汞荧光探针：用于活细胞和斑马鱼中汞生物成像的荧光开启检测。
Coumarin-based Hg fluorescent probe: Fluorescence turn-on detection for Hg bioimaging in living cells and zebrafish.
机构信息
Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300, Taiwan.
Organic and Polymer Synthesis Laboratory, Department of Chemistry, National Institute of Technology, Tiruchirappalli 620 015, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Aug 5;219:135-140. doi: 10.1016/j.saa.2019.04.048. Epub 2019 Apr 19.
The need in developing fluorescent probes for trace metal ion detection in biological samples has been an important issue. Herein, a reaction-based fluorescent probe PIC containing a perimidine moiety was designed and synthesized for Hg detection. The probe can selectively distinguish Hg with 42-fold fluorescent enhancement from the other metal ions at physiological pH. This probe can detect Hg with the detection limit of 1.08 μM. The sensor PIC can be applied to real-time detection of Hg in cells with blue emission.
开发用于生物样品中痕量金属离子检测的荧光探针一直是一个重要问题。在此，设计并合成了一种基于嘧啶结构的荧光探针 PIC 用于 Hg 的检测。该探针可以在生理 pH 值下选择性地识别 Hg，荧光增强 42 倍，与其他金属离子区分开来。该探针对 Hg 的检测限低至 1.08 μM。传感器 PIC 可以用于细胞中 Hg 的实时检测，发出蓝色荧光。
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