体重指数（BMI）的增加与子宫内膜癌而不是卵巢癌中的子宫内膜样和浆液性组织类型均相关：病例对照研究。
Increasing BMI is associated with both endometrioid and serous histotypes among endometrial rather than ovarian cancers: a case-to-case study.
机构信息
Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Via del Pozzo 71, 41124 Modena, Italy.
Gynecologic Oncology Unit, University of Bologna, Policlinico S.Orsola-Malpighi, Via Masserenti 13, 40138 Bologna, Italy.
出版信息
Gynecol Oncol. 2019 Jul;154(1):163-168. doi: 10.1016/j.ygyno.2019.04.684. Epub 2019 May 16.
AIM
Although obesity has been associated with endometrioid (type I) and, to a lesser extent, with serous (type II) endometrial cancer (EC), the association with the same histotypes of ovarian cancer (OC) remains unclear. Therefore, we intended to compare the role of BMI in carcinogenesis of endometrioid and the serous malignancies, at both ovarian and endometrial level.
METHODS
A retrospective case-to-case study was performed in the University Hospital of Bologna (Italy), through the review of primary EC matched with the corresponding OC cases in the same period (1988-2017).
RESULTS
We included 1052 women diagnosed with EC (n = 897 endometrioid, n = 52 serous) and 955 women affected by OC (n = 132 endometrioid, n = 627 serous). EC patients had higher median BMI than women diagnosed with OC (27.3 [23.4-31.9] vs 24.9 [21.7-27.5], p < 0.01). After controlling for confounding, 1 unit increase in BMI was associated with a 5% higher odds of endometrial as opposed to ovarian cancer (OR for ovarian as opposed to endometrial cancer 0.95; 95% CI 0.91-0.98, p = 0.004).
CONCLUSIONS
Increasing BMI is associated with endometrial rather than ovarian cancer, among both serous and endometrioid histotypes.
目的
尽管肥胖与子宫内膜样（I 型）癌，且在一定程度上与浆液性（II 型）子宫内膜癌相关，但与卵巢癌（OC）的相同组织类型的相关性尚不清楚。因此，我们旨在比较 BMI 在子宫内膜样和浆液性恶性肿瘤发生中的作用，包括卵巢和子宫内膜水平。
方法
在意大利博洛尼亚大学医院进行了回顾性病例对照研究，通过对同期（1988-2017 年）原发性子宫内膜癌病例与相应的 OC 病例进行了回顾性研究。
结果
我们纳入了 1052 名被诊断为 EC（n=897 例子宫内膜样，n=52 例浆液性）和 955 名患有 OC（n=132 例子宫内膜样，n=627 例浆液性）的女性患者。EC 患者的 BMI 中位数高于 OC 患者（27.3[23.4-31.9] vs 24.9[21.7-27.5]，p<0.01）。在控制混杂因素后，BMI 每增加 1 个单位，子宫内膜癌的发生几率就会增加 5%，而卵巢癌的发生几率则会降低 5%（OR 为 0.95；95%CI 为 0.91-0.98，p=0.004）。
结论
在浆液性和子宫内膜样组织类型中，BMI 的增加与子宫内膜癌而非卵巢癌相关。
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