择期足踝手术后 NSAID 给药对骨愈合的影响。
The effect of post-operative NSAID administration on bone healing after elective foot and ankle surgery.
机构信息
East Liverpool City Hospital, 425 W 5th St., East Liverpool, 43920, OH United States.
Austintown Podiatry Associates, 1300 S Canfield-Niles Rd #1, Austintown, 44515, OH, United States; The Orthopedic Surgery Center, 6505 Market St #101, Boardman, 44512, OH, United States.
出版信息
Foot Ankle Surg. 2020 Jun;26(4):457-463. doi: 10.1016/j.fas.2019.05.016. Epub 2019 May 31.
BACKGROUND
Post-operative pain is a common concern following elective foot and ankle surgery. NSAIDs used for pain relief have led to bone-healing complications in animal models and in vitro studies. This retrospective study examined the rate of bone-healing complications in post-surgical patients using NSAIDs.
METHODS
Participants underwent elective foot surgeries between January 2016 and May 2018. Radiographs were used to identify bony nonunion at osteotomy sites 12 weeks post-surgery.
RESULTS
Two-hundred thirty-two patients were evaluated; 59 (25.43%) were prescribed ibuprofen, 62 (27%) ketorolac, 15 (6.47%) acetaminophen, and 92 (40%) hydrocodone-acetaminophen. Two-hundred and twelve (91.38%) patients exhibited radiographic evidence of osseous union at 12 weeks and 20 (8.62%) had radiographic evidence of non-union of the osteotomy sites. There was no significant relationship between NSAID use and osseous non-union (p<0.05).
CONCLUSIONS
Short-term use of oral ibuprofen and ketorolac in the post-operative period was not associated with bony non-union.
背景
术后疼痛是足部和踝关节择期手术后常见的问题。用于缓解疼痛的 NSAIDs 在动物模型和体外研究中导致了骨愈合并发症。本回顾性研究检查了术后使用 NSAIDs 的患者的骨愈合并发症发生率。
方法
参与者在 2016 年 1 月至 2018 年 5 月期间接受了足部手术。术后 12 周，通过 X 光片确定截骨部位的骨不连。
结果
评估了 232 名患者；59 名（25.43%）患者开了布洛芬，62 名（27%）开了酮咯酸，15 名（6.47%）开了对乙酰氨基酚，92 名（40%）开了氢可酮-对乙酰氨基酚。221 名（91.38%）患者在 12 周时显示出骨骼愈合的影像学证据，20 名（8.62%）患者的截骨部位出现影像学证据的骨不连。NSAID 使用与骨不连之间没有显著关系（p<0.05）。
结论
术后短期使用口服布洛芬和酮咯酸与骨不连无关。
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