聚（ADP-核糖）聚合酶抑制剂对细胞介导和病毒介导的 HTLV-1 感染的冲突作用。
Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection.
机构信息
Department of Microbiology, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan; Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, Kagoshima 890-8544, Japan.
Department of Microbiology, Kansai Medical University, Hirakata, Osaka, 573-1010, Japan; Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, 526-0829, Japan.
出版信息
Virus Res. 2019 Sep;270:197653. doi: 10.1016/j.virusres.2019.197653. Epub 2019 Jul 9.
Adult T-cell leukemia and human T-cell leukemia virus type 1 (HTLV-1) - associated myelopathy/tropical spastic paraparesis, which develop after HTLV-1 infection, are difficult to cure. In particular, the mode of HTLV-1 propagation is not well understood. Poly (ADP-ribose) polymerase-1 is reported to be a co-activator of HTLV-1 Tax protein; however, the effects of polyADP-ribosylation on infectivity of HTLV-1 have not been fully clarified. We studied the effects of a PARP inhibitor on two modes of HTLV-1 transmission: through cell adhesion between MT-2 cells (an HTLV-1-infected cell line) and uninfected cells and through virus particles produced by HTLV-1-producing c77 cells. Although the PARP inhibitor decreased HTLV-1 infection through cell adhesion, it increased HTLV-1 infection through virion production and caused apoptosis of HTLV-1-infected cells. Thus, careful consideration is required for clinical application of PARP inhibitors in HTLV-1 patients.
成人 T 细胞白血病和人类 T 细胞白血病病毒 1（HTLV-1）相关的脊髓病/热带痉挛性截瘫，在 HTLV-1 感染后发展，难以治愈。特别是，HTLV-1 的传播模式尚未得到很好的理解。聚（ADP-核糖）聚合酶-1 被报道为 HTLV-1 Tax 蛋白的共激活剂；然而，聚 ADP-核糖基化对 HTLV-1 感染性的影响尚未完全阐明。我们研究了 PARP 抑制剂对 HTLV-1 两种传播模式的影响：通过 MT-2 细胞（HTLV-1 感染的细胞系）与未感染细胞之间的细胞黏附和通过 HTLV-1 产生的 c77 细胞产生的病毒颗粒。尽管 PARP 抑制剂降低了通过细胞黏附的 HTLV-1 感染，但它通过病毒颗粒的产生增加了 HTLV-1 感染，并导致 HTLV-1 感染细胞的凋亡。因此，在 HTLV-1 患者中应用 PARP 抑制剂需要谨慎考虑。
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