在无过渡金属条件下，BPO 促进的未活化烷烃的直接氧化 C-H 官能化生成 6-烷基-6H-苯并[c]色烯。

BPO-promoted direct oxidative C-H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions.

机构信息

School of Chemistry and Materials Science, Nanjing Normal University; Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210023, China.

出版信息

Org Biomol Chem. 2019 Sep 7;17(33):7715-7722. doi: 10.1039/c9ob01396b. Epub 2019 Aug 12.

DOI:10.1039/c9ob01396b

PMID:31402357

Abstract

A simple and efficient BPO-promoted free radical-based cascade reaction of biaryl vinyl ethers with easily available unactivated alkanes has been developed. A series of 6-alkyl-6H-benzo[c]chromenes have been successfully obtained in moderate to high yields under transition-metal-free conditions. This method can also be utilized to synthesize 6-alkyl-6H-benzo[c]thiochromenes from the corresponding biaryl vinyl thioethers.

摘要

一种简单高效的 BPO 促进的自由基级联反应，可使联芳基乙烯基醚与易得的非活性链烷烃反应。在无过渡金属条件下，以中等至高产率成功获得了一系列 6-烷基-6H-苯并[c]色烯。该方法还可用于从相应的联芳基乙烯基硫醚合成 6-烷基-6H-苯并[c]噻吩。