Natural Chemotherapeutics Research Laboratory, NIH/NIMHD RCMI-Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, Jackson, MS, USA.
Department of Epidemiology and Biostatistics, College of Public Service, Jackson State University, Jackson Medical Mall - Thad Cochran Center, Jackson, MS, USA.
Adv Exp Med Biol. 2019;1152:31-49. doi: 10.1007/978-3-030-20301-6_3.
Breast cancer is the most common noncutaneous malignancy and the second most lethal form of cancer among women in the United States. It currently affects more than one in ten women worldwide. The chance for a female to be diagnosed with breast cancer during her lifetime has significantly increased from 1 in 11 women in 1975 to 1 in 8 women (Altekruse, SEER Cancer Statistics Review, 1975-2007. National Cancer Institute, Bethesda, 2010). This chance for a female of being diagnosed with cancer generally increases with age (Howlader et al, SEER Cancer Statistics Review, 1975-2010. National Cancer Institute, Bethesda, 2013). Fortunately, the mortality rate from breast cancer has decreased in recent years due to increased emphasis on early detection and more effective treatments in the White population. Although the mortality rates have declined in some ethnic populations, the overall cancer incidence among African American and Hispanic population has continued to grow. The goal of the work presented in this book chapter is to highlight similarities and differences in breast cancer morbidity and mortality rates among non-Hispanic white and non-Hispanic black populations. This book chapter also provides an overview of breast cancer, racial/ethnic disparities in breast cancer, breast cancer incidence and mortality rate linked to hereditary, major risk factors of breast cancer among minority population, breast cancer treatment, and health disparity. A considerable amount of breast cancer treatment research have been conducted, but with limited success for African Americans compared to other ethnic groups. Therefore, new strategies and approaches are needed to promote breast cancer prevention, improve survival rates, reduce breast cancer mortality, and ultimately improve the health outcomes of racial/ethnic minorities. In addition, it is vital that leaders and medical professionals from minority population groups be represented in decision-making in research so that racial disparity in breast cancer can be well-studied, fully addressed, and ultimately eliminated in breast cancer.
乳腺癌是美国女性中最常见的非皮肤恶性肿瘤,也是第二大最致命的癌症类型。目前,全世界每十名女性中就有一人受到影响。女性一生中被诊断患有乳腺癌的几率从 1975 年每 11 名女性中就有 1 名增加到 1975 年每 8 名女性中就有 1 名(Altekruse,SEER Cancer Statistics Review,1975-2007。国家癌症研究所,贝塞斯达,2010)。女性被诊断患有癌症的几率通常会随着年龄的增长而增加(Howlader 等人,SEER Cancer Statistics Review,1975-2010。国家癌症研究所,贝塞斯达,2013)。幸运的是,由于在白人中更加重视早期发现和更有效的治疗,近年来乳腺癌的死亡率有所下降。尽管一些族裔群体的死亡率有所下降,但非裔美国人和西班牙裔人群的总体癌症发病率仍在继续增长。本章工作的目标是强调非西班牙裔白人和非西班牙裔黑人群体乳腺癌发病率和死亡率的异同。本章还概述了乳腺癌、乳腺癌的种族/民族差异、与遗传性相关的乳腺癌发病率和死亡率、少数族裔乳腺癌的主要危险因素、乳腺癌治疗和健康差距。已经进行了大量的乳腺癌治疗研究,但与其他族裔群体相比,非裔美国人的成功率有限。因此,需要新的策略和方法来促进乳腺癌预防、提高生存率、降低乳腺癌死亡率,并最终改善少数族裔的健康结果。此外,少数族裔群体的领导人以及医疗专业人员必须参与研究决策,以便对乳腺癌的种族差异进行深入研究,全面解决,并最终消除乳腺癌。