1947年至2018年寨卡病毒传播范围从非洲扩展至美洲：一项文献综述
Expansion of Zika virus circulation from Africa to the Americas, 1947-2018: a literature review.
作者信息
Sampaio Gilmara de Souza, Brites Carlos, Drexler Jan Felix, Moreira-Soto Andres, Miranda Fernanda, Martins Netto Eduardo
机构信息
Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Salvador, BA, Brasil.
Charité - Universitätsmedizin Berlin, Institut für Virologie, Berlim, Alemanha.
出版信息
Epidemiol Serv Saude. 2019 Aug 22;28(2):e2018411. doi: 10.5123/S1679-49742019000200022.
OBJECTIVE
to describe the temporal and geographical expansion of Zika virus (ZIKV) circulation in countries and territories, from the time it was first isolated until 2018.
METHODS
This was a non-systematic literature review covering the period from 1947 to 2018 using the MEDLINE database and World Health Organization estimates.
RESULTS
Since its isolation in 1947, ZIKV circulation spread through Africa, Asia and the Pacific before reaching the Americas in 2013, causing serious clinical manifestations; the highest seroprevalence rates were recorded in Yap (74%) and in Brazil (63%); genetic mutations, absence of immunity and high vector susceptibility may have influenced ZIKV transmissibility and help to explain the magnitude of its expansion.
CONCLUSION
The spread of ZIKV circulation in the Americas was the most extensive recorded thus far, possibly as a result of population and geographical characteristics of the sites where the virus circulated.
目的
描述寨卡病毒（ZIKV）在各国及各地区传播的时间和地理范围，从其首次分离至2018年。
方法
这是一项非系统性文献综述，利用MEDLINE数据库及世界卫生组织的估计数据，涵盖1947年至2018年期间。
结果
自1947年分离以来，寨卡病毒传播先在非洲、亚洲及太平洋地区扩散，于2013年抵达美洲，引发严重临床表现；血清阳性率最高的地区是雅浦岛（74%）和巴西（63%）；基因突变、缺乏免疫力以及媒介易感性高可能影响了寨卡病毒的传播能力，并有助于解释其传播范围之广。
结论
寨卡病毒在美洲的传播是迄今有记录以来最广泛的，这可能是该病毒传播地区的人口和地理特征所致。
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