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埃塞俄比亚西南部 Jimma 地区 Jimma 大学医学中心的 2 型糖尿病成年患者血糖控制不佳的决定因素:一项病例对照研究。

Determinants of poor glycemic control among adult patients with type 2 diabetes mellitus in Jimma University Medical Center, Jimma zone, south west Ethiopia: a case control study.

机构信息

Department of Pharmacy, College of medicine and health science, Mizan Tepi University, Mizan Teferi, Ethiopia.

Department of Pharmacy, Jimma University Institute of Health Science, Jimma, Ethiopia.

出版信息

BMC Endocr Disord. 2019 Aug 29;19(1):91. doi: 10.1186/s12902-019-0421-0.

Abstract

OBJECTIVE AND BACKGROUND

In 2015 approximately 5.0 million people were estimated to have died from diabetes. Poor glycemic control is the most determinant of diabetes-related complication and death. The percentage of patients whose blood glucose level are not well controlled remains high yet. The aim of this study is to identify the determinants of poor glycemic control at the diabetes clinic of the Jimma University Medical Center from April 01 to June 30/2017.

METHODS

Facility-based case-control study design was conducted on patients with type 2 diabetes mellitus on follow-up at the diabetes clinic of Jimma University medical center. The consecutive sampling technique was employed and data were collected from April to June 2017. The data were entered using Epidata manager version 4.0.2 and exported to SPSS Version 21 for analysis. Logistic regression analysis was performed and variables with the p-value of less than 0.05 were considered as statistically significant determinants of poor glycemic control.

RESULT

The study was conducted on 410 patients, of which 228 males and 182 females. The determinants of poor glycemic control were comorbidities [Adjusted odd ratio(AOR) = 2.56, 95%CI = 1.10-5.96], lack of self-monitoring blood glucose [AOR = 3.44,95%CI = 1.33-8.94], total cholesterol level of 200 mg/dl or more [AOR = 3.62, 95%CI = 1.46-8.97], diabetes duration of greater than 7 years [AOR = 3.08, 95%CI = 1.33-7.16], physical activity of three or less than three days [AOR = 4.79, 95%CI = 1.70-13.53], waist to hip ratio of 0.9 or greater for male and 0.85 or greater for female [AOR = 3.52, 95%CI = 1.23-10.11], being on metformin plus insulin [AOR = 9.22, 95%CI = 2.90-29.35] and being on insulin [AOR = 4.48, 95%CI = 1.52-13.16].

CONCLUSION

Lack of Self-monitoring blood glucose, presence of comorbidities, duration of diabetes mellitus, physical activity of three or less than three days, total cholesterol of 200 mg/dl or more, waist to hip ratio of 0.9 or greater for male and 0.85 or greater for female, and types of antidiabetic medication were the independent predictors of poor glycemic control. Effort should be made towards reducing these factors by the concerned body.

摘要

目的和背景

2015 年,全球约有 500 万人死于糖尿病。血糖控制不佳是糖尿病相关并发症和死亡的最主要决定因素。然而,血糖控制不佳的患者比例仍然很高。本研究旨在 2017 年 4 月 1 日至 6 月 30 日期间,确定 Jimma 大学医学中心糖尿病诊所患者血糖控制不佳的决定因素。

方法

在 Jimma 大学医学中心糖尿病诊所接受随访的 2 型糖尿病患者中进行了基于设施的病例对照研究设计。采用连续抽样技术,于 2017 年 4 月至 6 月期间收集数据。数据使用 Epidata 经理版本 4.0.2 输入,并导出到 SPSS 版本 21 进行分析。进行逻辑回归分析,将 p 值小于 0.05 的变量视为血糖控制不佳的统计学显著决定因素。

结果

本研究共纳入 410 例患者,其中男性 228 例,女性 182 例。血糖控制不佳的决定因素包括合并症[调整后的比值比(AOR)=2.56,95%置信区间(CI)=1.10-5.96]、缺乏自我监测血糖[AOR=3.44,95%CI=1.33-8.94]、总胆固醇水平为 200mg/dl 或更高[AOR=3.62,95%CI=1.46-8.97]、糖尿病病程大于 7 年[AOR=3.08,95%CI=1.33-7.16]、每周运动 3 天或更少[AOR=4.79,95%CI=1.70-13.53]、男性腰臀比为 0.9 或更大,女性腰臀比为 0.85 或更大[AOR=3.52,95%CI=1.23-10.11]、使用二甲双胍加胰岛素[AOR=9.22,95%CI=2.90-29.35]和使用胰岛素[AOR=4.48,95%CI=1.52-13.16]。

结论

缺乏自我监测血糖、合并症、糖尿病病程、每周运动 3 天或更少、总胆固醇水平为 200mg/dl 或更高、男性腰臀比为 0.9 或更大,女性腰臀比为 0.85 或更大、以及糖尿病药物类型是血糖控制不佳的独立预测因素。有关机构应努力减少这些因素。

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