15-脱氧-Δ¹²-前列腺素J2（15d-PGJ2），过氧化物酶体增殖物激活受体-γ的内源性配体：功能与机制
15-Deoxy-∆--Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-: Function and Mechanism.
作者信息
Li Jingjing, Guo Chuanyong, Wu Jianye
机构信息
Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China.
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
出版信息
PPAR Res. 2019 Aug 1;2019:7242030. doi: 10.1155/2019/7242030. eCollection 2019.
15-Deoxy-∆--prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor- (PPAR-) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR- signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR- receptor agonists have been developed, as an endogenous product of PPAR- receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.
15-脱氧-Δ¹²-前列腺素J2（15d-PGJ2）是一种天然的过氧化物酶体增殖物激活受体-γ（PPAR-γ）激动剂，在过去20年中已得到较为详细的研究。通过触发PPAR-γ信号通路，它发挥多种作用，并具有抗肿瘤、抗炎、抗氧化、抗纤维化和抗血管生成作用。尽管已经开发出许多合成的PPAR-γ受体激动剂，但作为PPAR-γ受体的内源性产物，15d-PGJ2具有包括快速表达和有助于天然防御机制等有益特性。在本综述中，我们讨论了通过PPAR-γ介导的15d-PGJ2生物学作用的最新研究进展。了解其结构、合成和功能机制对于开发预防药物和限制相关疾病的进展非常重要。
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