正电子发射断层扫描（PET）对介入肿瘤学手术免疫效应的评估

PET Assessment of Immune Effects from Interventional Oncology Procedures.

作者信息

Hunt Stephen J, Seraj Siavash Mehdizadeh, Alavi Abass

机构信息

Hospital of the University of Pennsylvania, Perelman School of Medicine, 3400 Spruce St., 1 Silverstein, Philadelphia, PA 19104, USA.

出版信息

PET Clin. 2019 Oct;14(4):477-485. doi: 10.1016/j.cpet.2019.06.007.

DOI:10.1016/j.cpet.2019.06.007

PMID:31472745

Abstract

Interventional oncology treatments have profound effects on tumor immunity. Quantitative molecular imaging with FDG-PET has the potential to aid in understanding baseline tumor characteristics that can predict response to interventional oncology treatments and immunotherapy. This review highlights some of the evidence for immune activation in the setting of locoregional therapies, and the patterns of treatment response that may be expected in the setting of immune induction. Also presented is an argument for measuring global disease metabolic activity over conventional methods of PET quantitation to circumvent challenges in correlating conventional methods of PET quantification to overall disease activity.

摘要

介入肿瘤学治疗对肿瘤免疫有深远影响。FDG-PET定量分子成像有助于了解基线肿瘤特征，这些特征可预测对介入肿瘤学治疗和免疫治疗的反应。本综述重点介绍了局部区域治疗中免疫激活的一些证据，以及免疫诱导情况下可能出现的治疗反应模式。还提出了一种观点，即通过测量整体疾病代谢活性而非传统的PET定量方法，以规避将传统PET定量方法与整体疾病活性相关联时所面临的挑战。